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• W2564278059 endingPage "e0152252" @default.
• W2564278059 startingPage "e0152252" @default.
• W2564278059 abstract "A competition of neurobehavioral drives of sleep and wakefulness occurs during sleep deprivation. When enforced chronically, subjects must remain awake. This study examines histaminergic neurons of the tuberomammillary nucleus of the posterior hypothalamus in response to enforced wakefulness in rats. We tested the hypothesis that the rate-limiting enzyme for histamine biosynthesis, L-histidine decarboxylase (HDC), would be up-regulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Archived brain tissues of male Sprague Dawley rats from a previous study were used. Rats had been subjected to REM-SD by the flowerpot paradigm for 5, 10, or 15 days. For immunocytochemistry, rats were transcardially perfused with acrolein-paraformaldehyde for immunodetection of L-HDC; separate controls used carbodiimide-paraformaldehyde for immunodetection of histamine. Immunolocalization of histamine within the tuberomammillary nucleus was validated using carbodiimide. Because HDC antiserum has cross-reactivity with other decarboxylases at high antibody concentrations, titrations localized L-HDC to only tuberomammillary nucleus at a dilution of ≥ 1:300,000. REM-SD increased immunoreactive HDC by day 5 and it remained elevated in both dorsal and ventral aspects of the tuberomammillary complex. Our results suggest that up-regulation of L-HDC within the tuberomammillary complex during chronic REM-SD may be responsible for maintaining wakefulness." @default.
• W2564278059 created "2017-01-06" @default.
• W2564278059 creator A5014853779 @default.
• W2564278059 creator A5047537116 @default.
• W2564278059 date "2016-12-20" @default.
• W2564278059 modified "2023-09-24" @default.
• W2564278059 title "Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During Chronic REM Sleep Deprivation of Rats" @default.
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• W2564278059 doi "https://doi.org/10.1371/journal.pone.0152252" @default.
• W2564278059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5172538" @default.
• W2564278059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27997552" @default.
• W2564278059 hasPublicationYear "2016" @default.
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