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- W2564332559 abstract "With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HBcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy." @default.
- W2564332559 created "2017-01-06" @default.
- W2564332559 creator A5032428542 @default.
- W2564332559 creator A5063550464 @default.
- W2564332559 date "2016-12-25" @default.
- W2564332559 modified "2023-10-18" @default.
- W2564332559 title "New perspectives of biomarkers for the management of chronic hepatitis B" @default.
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- W2564332559 doi "https://doi.org/10.3350/cmh.2016.0069" @default.
- W2564332559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5266347" @default.
- W2564332559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28081591" @default.
- W2564332559 hasPublicationYear "2016" @default.
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