Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564354914> ?p ?o ?g. }
- W2564354914 endingPage "1601041" @default.
- W2564354914 startingPage "1601041" @default.
- W2564354914 abstract "It has been nearly two decades since RNA-interference (RNAi) was first reported. While there are no approved clinical uses, several phase II and III clinical trials suggest the great promise of RNAi therapeutics. One challenge for RNAi therapies is the controlled localization and sustained presentation to target tissues, to both overcome systemic toxicity concerns and to enhance in vivo efficacy. One approach that is emerging to address these limitations is the entrapment of RNAi molecules within hydrogels for local and sustained release. In these systems, nucleic acids are either delivered as siRNA conjugates or within nanoparticles. A plethora of hydrogels has been implemented using these approaches, including both traditional hydrogels that have already been developed for other applications and new hydrogels developed specifically for RNAi delivery. These hydrogels have been applied to various applications in vivo, including cancer, bone regeneration, inflammation and cardiac repair. This review will examine the design and implementation of such hydrogel RNAi systems and will cover the most recent applications of these systems." @default.
- W2564354914 created "2017-01-06" @default.
- W2564354914 creator A5026268740 @default.
- W2564354914 creator A5026844565 @default.
- W2564354914 date "2016-12-15" @default.
- W2564354914 modified "2023-10-03" @default.
- W2564354914 title "Engineered Hydrogels for Local and Sustained Delivery of RNA-Interference Therapies" @default.
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