FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564370823> ?p ?o ?g. }

• W2564370823 endingPage "6619" @default.
• W2564370823 startingPage "6609" @default.
• W2564370823 abstract "This study aimed to evaluate aminoclay (3-aminopropyl-functionalized magnesium phyllosilicate) as an effective protectant for the stabilization of protein formulation in freeze-drying. Bovine serum albumin (BSA), as a model protein, was freeze-dried with aminoclay at various concentrations, and the effects of aminoclay on the structural stability of proteins were compared with those of the conventional stabilizers. The structural characteristics of the protein were determined by size exclusion chromatography (SEC), circular dichroism (CD), and Fourier transform infrared (FTIR) spectroscopy. Furthermore, physicochemical and morphological characteristics were examined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). XRPD and DSC patterns indicated that the glass transition temperature (Tg) of the amorphous formulation of aminoclay mixed with proteins was gradually elevated as the concentration of aminoclay increased. FTIR and CD spectral analysis suggested that the protein structure was well maintained with aminoclay during the freeze-drying process and 3 months of storage at 4°C and 40°C. Furthermore, aminoclay conferred the greatest protection against aggregation and retained the monomer content of BSA even at a high temperature. The morphological characteristics of lyophilized proteins were also well conserved during the storage with aminoclay. These results suggested that aminoclay may be useful as an alternative stabilizer for maintaining the structural stability of protein formulations." @default.
• W2564370823 created "2017-01-06" @default.
• W2564370823 creator A5005587867 @default.
• W2564370823 creator A5019886336 @default.
• W2564370823 creator A5028711165 @default.
• W2564370823 date "2016-12-01" @default.
• W2564370823 modified "2023-10-17" @default.
• W2564370823 title "Biophysical evaluation of aminoclay as an effective protectant for protein stabilization during freeze-drying and storage" @default.
• W2564370823 cites W1276324155 @default.
• W2564370823 cites W1494681965 @default.
• W2564370823 cites W1511036913 @default.
• W2564370823 cites W1562476096 @default.
• W2564370823 cites W1581858536 @default.
• W2564370823 cites W183938186 @default.
• W2564370823 cites W1963482639 @default.
• W2564370823 cites W1964198706 @default.
• W2564370823 cites W1966234811 @default.
• W2564370823 cites W1977247557 @default.
• W2564370823 cites W1984904502 @default.
• W2564370823 cites W1988256370 @default.
• W2564370823 cites W1997772494 @default.
• W2564370823 cites W1998361394 @default.
• W2564370823 cites W2003021861 @default.
• W2564370823 cites W2013518551 @default.
• W2564370823 cites W2014664428 @default.
• W2564370823 cites W2025912948 @default.
• W2564370823 cites W2029948026 @default.
• W2564370823 cites W2056890384 @default.
• W2564370823 cites W2059564760 @default.
• W2564370823 cites W2067721839 @default.
• W2564370823 cites W2067848480 @default.
• W2564370823 cites W2070088688 @default.
• W2564370823 cites W2075050043 @default.
• W2564370823 cites W2077231187 @default.
• W2564370823 cites W2081212616 @default.
• W2564370823 cites W2081640562 @default.
• W2564370823 cites W2091109073 @default.
• W2564370823 cites W2132912202 @default.
• W2564370823 cites W2157065298 @default.
• W2564370823 cites W2157544220 @default.
• W2564370823 cites W2159709470 @default.
• W2564370823 cites W2165234277 @default.
• W2564370823 cites W2296976596 @default.
• W2564370823 cites W2302457478 @default.
• W2564370823 cites W2313687911 @default.
• W2564370823 cites W2322506573 @default.
• W2564370823 doi "https://doi.org/10.2147/ijn.s122726" @default.
• W2564370823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5161340" @default.
• W2564370823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28003745" @default.
• W2564370823 hasPublicationYear "2016" @default.
• W2564370823 type Work @default.
• W2564370823 sameAs 2564370823 @default.
• W2564370823 citedByCount "22" @default.
• W2564370823 countsByYear W25643708232017 @default.
• W2564370823 countsByYear W25643708232018 @default.
• W2564370823 countsByYear W25643708232019 @default.
• W2564370823 countsByYear W25643708232020 @default.
• W2564370823 countsByYear W25643708232021 @default.
• W2564370823 countsByYear W25643708232022 @default.
• W2564370823 countsByYear W25643708232023 @default.
• W2564370823 crossrefType "journal-article" @default.
• W2564370823 hasAuthorship W2564370823A5005587867 @default.
• W2564370823 hasAuthorship W2564370823A5019886336 @default.
• W2564370823 hasAuthorship W2564370823A5028711165 @default.
• W2564370823 hasBestOaLocation W25643708231 @default.
• W2564370823 hasConcept C121332964 @default.
• W2564370823 hasConcept C122865956 @default.
• W2564370823 hasConcept C127413603 @default.
• W2564370823 hasConcept C133571119 @default.
• W2564370823 hasConcept C13965031 @default.
• W2564370823 hasConcept C159985019 @default.
• W2564370823 hasConcept C160892712 @default.
• W2564370823 hasConcept C166940927 @default.
• W2564370823 hasConcept C178790620 @default.
• W2564370823 hasConcept C185039092 @default.
• W2564370823 hasConcept C185592680 @default.
• W2564370823 hasConcept C192562407 @default.
• W2564370823 hasConcept C26771246 @default.
• W2564370823 hasConcept C39519442 @default.
• W2564370823 hasConcept C42360764 @default.
• W2564370823 hasConcept C43617362 @default.
• W2564370823 hasConcept C521977710 @default.
• W2564370823 hasConcept C8010536 @default.
• W2564370823 hasConcept C84199377 @default.
• W2564370823 hasConcept C86807702 @default.
• W2564370823 hasConcept C97355855 @default.
• W2564370823 hasConceptScore W2564370823C121332964 @default.
• W2564370823 hasConceptScore W2564370823C122865956 @default.
• W2564370823 hasConceptScore W2564370823C127413603 @default.
• W2564370823 hasConceptScore W2564370823C133571119 @default.
• W2564370823 hasConceptScore W2564370823C13965031 @default.
• W2564370823 hasConceptScore W2564370823C159985019 @default.
• W2564370823 hasConceptScore W2564370823C160892712 @default.
• W2564370823 hasConceptScore W2564370823C166940927 @default.
• W2564370823 hasConceptScore W2564370823C178790620 @default.
• W2564370823 hasConceptScore W2564370823C185039092 @default.
• W2564370823 hasConceptScore W2564370823C185592680 @default.
• W2564370823 hasConceptScore W2564370823C192562407 @default.

• next