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- W2564373968 endingPage "1600764" @default.
- W2564373968 startingPage "1600764" @default.
- W2564373968 abstract "The incidence of stage I and II nonsmall cell lung cancer is likely to increase with the ageing population and introduction of screening for high-risk individuals. Optimal management requires multidisciplinary collaboration. Local treatments include surgery and radiotherapy and these are currently combined with (neo)adjuvant chemotherapy in specific cases to improve long-term outcome. Targeted therapies and immunotherapy may also become important therapeutic modalities in this patient group. For resectable disease in patients with low cardiopulmonary risk, complete surgical resection with lobectomy remains the gold standard. Minimally invasive techniques, conservative and sublobar resections are suitable for a subset of patients. Data are emerging that radiotherapy, especially stereotactic body radiation therapy, is a valid alternative in compromised patients who are high-risk candidates for surgery. Whether this is also true for good surgical candidates remains to be evaluated in randomised trials. In specific subgroups adjuvant chemotherapy has been shown to prolong survival; however, patient selection remains important. Neoadjuvant chemotherapy may yield similar results as adjuvant chemotherapy. The role of targeted therapies and immunotherapy in early stage nonsmall cell lung cancer has not yet been determined and results of randomised trials are awaited." @default.
- W2564373968 created "2017-01-06" @default.
- W2564373968 creator A5001400077 @default.
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- W2564373968 creator A5022776597 @default.
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- W2564373968 date "2016-12-23" @default.
- W2564373968 modified "2023-10-14" @default.
- W2564373968 title "Management of stage I and II nonsmall cell lung cancer" @default.
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