FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564386469> ?p ?o ?g. }

• W2564386469 abstract "Colorectal cancer (CRC) is the third most common type of cancer in the world with a low survival rate and therapeutic efficiency. Tumor surgery implies the removal of an apparently non-tumorous tissue around the tumor in an attempt to reduce recurrence chances; this tissue is referred to as the resection margin. Our analysis employed an 8-plex iTRAQ to label four adenocarcinoma biopsies and their corresponding resection margins at 5cm; our results disclose fifty-six proteins as being differentially abundant. These proteins are mainly involved in energetic metabolism (e.g. S100 calcium binding protein A11), cell migration (e.g. transgelin), formation of the cytoskeleton (e.g. profilin 1) and degradation of extracellular matrix (e.g. carbonic anhydrase 2). A gene ontology enrichment analysis revealed several proteins related to adhesion, invasion, metastasis, death, and recognition cell. Taken together, our results highlight proteins related to invasion, cell proliferation, and linked to the metastasis of colorectal cancer in tumor tissue. Finally, we argue that the expression patterns revealed in our comparison helps shed light on the development of more effective surgical strategies and add to the comprehension of this disease.Colorectal cancer (CRC) is the third most common type of cancer in the world with a low survival rate and therapeutic efficiency. Tumor surgery implies the removal of an apparently non-tumorous tissue around the tumor in an attempt to reduce recurrence chances; this tissue is also referred to as the resection margin. In this regard, resection margins pose as a treasure trove for investigating the molecular characteristics of the tumorigenesis process. While most studies focus on comparing cancer versus control tissue, this study contrasts the proteomic profiles of colorectal cancer biopsies with their corresponding resection margin at 5cm apart. Our analysis employed an 8-plex iTRAQ labeling and a 4-step offline MudPIT online with a Velos. A gene ontology enrichment analysis revealed several proteins related to adhesion, invasion, metastasis, death, and recognition cell." @default.
• W2564386469 created "2017-01-06" @default.
• W2564386469 creator A5004133180 @default.
• W2564386469 creator A5012217369 @default.
• W2564386469 creator A5021777617 @default.
• W2564386469 creator A5036876475 @default.
• W2564386469 creator A5038078186 @default.
• W2564386469 creator A5038367294 @default.
• W2564386469 creator A5039755087 @default.
• W2564386469 creator A5061013916 @default.
• W2564386469 date "2017-02-01" @default.
• W2564386469 modified "2023-09-24" @default.
• W2564386469 title "Proteomic assessment of colorectal cancers and respective resection margins from patients of the Amazon state of Brazil" @default.
• W2564386469 cites W145588642 @default.
• W2564386469 cites W146744847 @default.
• W2564386469 cites W1574900767 @default.
• W2564386469 cites W1574940207 @default.
• W2564386469 cites W1679079033 @default.
• W2564386469 cites W1750974667 @default.
• W2564386469 cites W1972291689 @default.
• W2564386469 cites W1976570855 @default.
• W2564386469 cites W1979522770 @default.
• W2564386469 cites W1985497018 @default.
• W2564386469 cites W1987355385 @default.
• W2564386469 cites W1987515837 @default.
• W2564386469 cites W1990065094 @default.
• W2564386469 cites W1990660755 @default.
• W2564386469 cites W1996333548 @default.
• W2564386469 cites W2004407038 @default.
• W2564386469 cites W2017897242 @default.
• W2564386469 cites W2018222126 @default.
• W2564386469 cites W2020142455 @default.
• W2564386469 cites W2025422229 @default.
• W2564386469 cites W2028092741 @default.
• W2564386469 cites W2028897202 @default.
• W2564386469 cites W2030732255 @default.
• W2564386469 cites W2032604597 @default.
• W2564386469 cites W2037513603 @default.
• W2564386469 cites W2040385802 @default.
• W2564386469 cites W2040452711 @default.
• W2564386469 cites W2046875430 @default.
• W2564386469 cites W2054960873 @default.
• W2564386469 cites W2055917979 @default.
• W2564386469 cites W2061321571 @default.
• W2564386469 cites W2062017840 @default.
• W2564386469 cites W2068880845 @default.
• W2564386469 cites W2077192459 @default.
• W2564386469 cites W2080133335 @default.
• W2564386469 cites W2080796958 @default.
• W2564386469 cites W2087481305 @default.
• W2564386469 cites W2088504528 @default.
• W2564386469 cites W2088561818 @default.
• W2564386469 cites W2089273345 @default.
• W2564386469 cites W2093628776 @default.
• W2564386469 cites W2098685167 @default.
• W2564386469 cites W2107036198 @default.
• W2564386469 cites W2108509187 @default.
• W2564386469 cites W2115007450 @default.
• W2564386469 cites W2115884477 @default.
• W2564386469 cites W2116201301 @default.
• W2564386469 cites W2124000950 @default.
• W2564386469 cites W2126029031 @default.
• W2564386469 cites W2128424949 @default.
• W2564386469 cites W2132208874 @default.
• W2564386469 cites W2133445370 @default.
• W2564386469 cites W2134344008 @default.
• W2564386469 cites W2148104731 @default.
• W2564386469 cites W2148137405 @default.
• W2564386469 cites W2159419198 @default.
• W2564386469 cites W2161854746 @default.
• W2564386469 cites W2163793380 @default.
• W2564386469 cites W2165575535 @default.
• W2564386469 cites W2171769799 @default.
• W2564386469 cites W2196345157 @default.
• W2564386469 cites W2252051232 @default.
• W2564386469 cites W2261996664 @default.
• W2564386469 cites W2262976102 @default.
• W2564386469 cites W2274740085 @default.
• W2564386469 cites W2278966580 @default.
• W2564386469 cites W2293615304 @default.
• W2564386469 cites W2317477512 @default.
• W2564386469 cites W2377806452 @default.
• W2564386469 cites W2395251530 @default.
• W2564386469 cites W2417052817 @default.
• W2564386469 cites W2419001748 @default.
• W2564386469 doi "https://doi.org/10.1016/j.jprot.2016.12.004" @default.
• W2564386469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27986506" @default.
• W2564386469 hasPublicationYear "2017" @default.
• W2564386469 type Work @default.
• W2564386469 sameAs 2564386469 @default.
• W2564386469 citedByCount "3" @default.
• W2564386469 countsByYear W25643864692018 @default.
• W2564386469 countsByYear W25643864692020 @default.
• W2564386469 crossrefType "journal-article" @default.
• W2564386469 hasAuthorship W2564386469A5004133180 @default.
• W2564386469 hasAuthorship W2564386469A5012217369 @default.
• W2564386469 hasAuthorship W2564386469A5021777617 @default.
• W2564386469 hasAuthorship W2564386469A5036876475 @default.
• W2564386469 hasAuthorship W2564386469A5038078186 @default.
• W2564386469 hasAuthorship W2564386469A5038367294 @default.

• next