FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564407384> ?p ?o ?g. }

• W2564407384 abstract "The multi-resistant Staphylococcus capitis clone NRCS-A has recently been described as a major pathogen causing nosocomial, late-onset sepsis (LOS) in preterm neonates worldwide. NRCS-A representatives exhibit an atypical antibiotic resistance profile. Here, the complete closed genome (chromosomal and plasmid sequences) of NRCS-A prototype strain CR01 and the draft genomes of three other clinical NRCS-A strains from Australia, Belgium and the United Kingdom are annotated and compared to available non-NRCS-A S. capitis genomes. Our goal was to delineate the uniqueness of the NRCS-A clone with respect to antibiotic resistance, virulence factors and mobile genetic elements. We identified 6 antimicrobial resistance genes, all carried by mobile genetic elements. Previously described virulence genes present in the NRCS-A genomes are shared with the six non-NRCS-A S. capitis genomes. Overall, 63 genes are specific to the NRCS-A lineage, including 28 genes located in the methicillin-resistance cassette SCCmec. Among the 35 remaining genes, 25 are of unknown function, and 9 correspond to an additional type I restriction modification system (n=3), a cytosine methylation operon (n=2), and a cluster of genes related to the biosynthesis of teichoic acids (n=4). Interestingly, a tenth gene corresponds to a resistance determinant for nisin (nsr gene), a bacteriocin secreted by potential NRCS-A strain niche competitors in the gut microbiota. The genomic characteristics presented here emphasize the contribution of mobile genetic elements to the emergence of multidrug resistance in the S. capitis NRCS-A clone. No NRCS-A-specific known virulence determinant was detected, which does not support a role for virulence as a driving force of NRCS-A emergence in NICUs worldwide. However, the presence of a nisin resistance determinant on the NRCS-A chromosome, but not in other S. capitis strains and most coagulase-negative representatives, might confer a competitive advantage to NRCS-A strains during the early steps of gut colonization in neonates. This suggests that the striking adaptation of NRCS-A to the NICU environment might be related to its specific antimicrobial resistance and also to a possible enhanced ability to challenge competing bacteria in its ecological niche." @default.
• W2564407384 created "2017-01-06" @default.
• W2564407384 creator A5011379957 @default.
• W2564407384 creator A5024203320 @default.
• W2564407384 creator A5027131675 @default.
• W2564407384 creator A5032016336 @default.
• W2564407384 creator A5042515876 @default.
• W2564407384 creator A5045613894 @default.
• W2564407384 creator A5063350863 @default.
• W2564407384 creator A5069009054 @default.
• W2564407384 creator A5084826885 @default.
• W2564407384 creator A5090625291 @default.
• W2564407384 date "2016-12-15" @default.
• W2564407384 modified "2023-10-16" @default.
• W2564407384 title "Single-Molecule Sequencing (PacBio) of the Staphylococcus capitis NRCS-A Clone Reveals the Basis of Multidrug Resistance and Adaptation to the Neonatal Intensive Care Unit Environment" @default.
• W2564407384 cites W1480382811 @default.
• W2564407384 cites W1532327591 @default.
• W2564407384 cites W1575909346 @default.
• W2564407384 cites W1878688897 @default.
• W2564407384 cites W1967779392 @default.
• W2564407384 cites W1982579644 @default.
• W2564407384 cites W1983403167 @default.
• W2564407384 cites W1984402144 @default.
• W2564407384 cites W1984476228 @default.
• W2564407384 cites W1984783889 @default.
• W2564407384 cites W1992775178 @default.
• W2564407384 cites W2012539366 @default.
• W2564407384 cites W2017046795 @default.
• W2564407384 cites W2022316530 @default.
• W2564407384 cites W2026482455 @default.
• W2564407384 cites W2029037152 @default.
• W2564407384 cites W2033829450 @default.
• W2564407384 cites W2035387676 @default.
• W2564407384 cites W2041257508 @default.
• W2564407384 cites W2042100571 @default.
• W2564407384 cites W2049581459 @default.
• W2564407384 cites W2055530572 @default.
• W2564407384 cites W2070748522 @default.
• W2564407384 cites W2071337370 @default.
• W2564407384 cites W2072572024 @default.
• W2564407384 cites W2072967720 @default.
• W2564407384 cites W2073518110 @default.
• W2564407384 cites W2073550483 @default.
• W2564407384 cites W2085329636 @default.
• W2564407384 cites W2088226054 @default.
• W2564407384 cites W2095849700 @default.
• W2564407384 cites W2099063549 @default.
• W2564407384 cites W2099837668 @default.
• W2564407384 cites W2100363512 @default.
• W2564407384 cites W2125591244 @default.
• W2564407384 cites W2126915534 @default.
• W2564407384 cites W2130483157 @default.
• W2564407384 cites W2132507135 @default.
• W2564407384 cites W2132861164 @default.
• W2564407384 cites W2133315012 @default.
• W2564407384 cites W2134829583 @default.
• W2564407384 cites W2137061133 @default.
• W2564407384 cites W2142678478 @default.
• W2564407384 cites W2148851922 @default.
• W2564407384 cites W2149452073 @default.
• W2564407384 cites W2159721380 @default.
• W2564407384 cites W2165562761 @default.
• W2564407384 cites W2171998389 @default.
• W2564407384 cites W2233236537 @default.
• W2564407384 cites W2326826612 @default.
• W2564407384 cites W4231539689 @default.
• W2564407384 doi "https://doi.org/10.3389/fmicb.2016.01991" @default.
• W2564407384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5157051" @default.
• W2564407384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28018320" @default.
• W2564407384 hasPublicationYear "2016" @default.
• W2564407384 type Work @default.
• W2564407384 sameAs 2564407384 @default.
• W2564407384 citedByCount "14" @default.
• W2564407384 countsByYear W25644073842018 @default.
• W2564407384 countsByYear W25644073842019 @default.
• W2564407384 countsByYear W25644073842020 @default.
• W2564407384 countsByYear W25644073842021 @default.
• W2564407384 countsByYear W25644073842022 @default.
• W2564407384 countsByYear W25644073842023 @default.
• W2564407384 crossrefType "journal-article" @default.
• W2564407384 hasAuthorship W2564407384A5011379957 @default.
• W2564407384 hasAuthorship W2564407384A5024203320 @default.
• W2564407384 hasAuthorship W2564407384A5027131675 @default.
• W2564407384 hasAuthorship W2564407384A5032016336 @default.
• W2564407384 hasAuthorship W2564407384A5042515876 @default.
• W2564407384 hasAuthorship W2564407384A5045613894 @default.
• W2564407384 hasAuthorship W2564407384A5063350863 @default.
• W2564407384 hasAuthorship W2564407384A5069009054 @default.
• W2564407384 hasAuthorship W2564407384A5084826885 @default.
• W2564407384 hasAuthorship W2564407384A5090625291 @default.
• W2564407384 hasBestOaLocation W25644073841 @default.
• W2564407384 hasConcept C104317684 @default.
• W2564407384 hasConcept C132533263 @default.
• W2564407384 hasConcept C141231307 @default.
• W2564407384 hasConcept C22744801 @default.
• W2564407384 hasConcept C523546767 @default.
• W2564407384 hasConcept C54355233 @default.
• W2564407384 hasConcept C81089528 @default.
• W2564407384 hasConcept C86803240 @default.
• W2564407384 hasConcept C89423630 @default.

• next