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• W256448246 abstract "The reciprocal translocations t(8;21) and t(15;17) are among the most common chromosomal aberrations in patients (pts.) with acute myeloblastic leukemia (AML). Both translocations result in chimeric fusion mRNAs [AML1/ETO for t(8;21) and PML/RARa for t(15;17)] which can be detected by specific amplification with reverse transcriptase polymerase chain reaction (RT-PCR). In addition to primary diagnosis, RT-PCR can be used in these pts. for the sensitive monitoring of minimal residual disease (MRD) in complete remission (CR) after intensive polychemotherapy. In this study, we analysed 9 pts. with t(8;21) and 16 pts. with t(15;17) in CR for MRD using nested RT-PCR for AML1/ETO and PML/RARa. In the t(8;21) group 4/9 pts. became PCR-negative after induction and/or consolidation therapy; 3 of these pts. are in ongoing CR after 12 to 72 months (mo). 1 pt. relapsed after 24 mo. 5/9 pts. remained PCRpositive after chemotherapy; 3 of these pts. are in ongoing CR after 2 to 48 mo, 1 pt. relapsed after 12 mo and 1 pt. died in CR. In the t(15;17) group 15/16 pts. became PCR-negative after 1 or 2 cycles of induction chemotherapy. 13 of these pts. are in ongoing CR after 3 to 78 mo. 2 pts relapsed after 21 and 22 mo. and in both pts. clinical relapse was preceeded by the recurrence of PML/RARα fusion transcripts in morphological CR. 1/16 pts. remained PCR-positive after induction and consolidation therapy but became negative after allogeneic bone marrow transplantation and is in CR after 15 mo. Taken together, in most of the t(15;17) positive AML pts. the leukemic clone can be reduced below the detection level by aggressive chemotherapy. Because the recurrence of PML/RARa transcripts in CR is correlated with later clinical relapse, serial PCR-analyses should be performed in these pts. In contrast, a considerable proportion of AML-pts. with t(8;21) remain PCR-positive after chemotherapy apparently without correlation to clinical outcome. Further prospective studies are necessary to determine whether PCR-analyses are of clinical relevance in these pts." @default.
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• W256448246 date "1998-01-01" @default.
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• W256448246 title "RT-PCR for the Detection of Minimal Residual Disease in Acute Myeloblastic Leukemia with t(8;21) and t(15;17)" @default.
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• W256448246 doi "https://doi.org/10.1007/978-3-642-71960-8_142" @default.
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