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- W2564518265 abstract "Treatment of children with non-Hodgkin's lymphoma (NHL) with intensive combined modality regimens, incorporating combination chemotherapy, involved field radiotherapy and prophylaxis of the central nervous system, reproducibly cures the majority, as demonstrated by a number of reports [14]. Cure of a majority of cases ought not to mask however the considerable heterogeneity characteristic of NHL, either in adult or pediatric age groups. While virtually all lymphomas in children are high grade malignancies, sig nificant differences in the relapse hazard with modern therapy are related to the primary site, stage and immunopathologic subtype (T or B). A rational strategy for success in management of childhood NHL therefore requires consideration of these factors. The review will outline such a strategy, rationale and recent results. Table 1. A clinical staging classification for childhood NHL Stage Criteria for extent of disease I A single tumor (extranodal) or single anatomic areas (nodal), with the exclusion of mediastinum or abdomen. II A single tumor (extranodal) with regional node involvement. Two or more nodal areas on the same side of the diaphragm. Two single (extranodal) tumors with or without regional node involvement on the same side of the diaphragm. A primary gastrointestinal tract tumor, usually in the ileocecal area, with or without involvement of associated mesenteric nodes only, grossly completely resected. III Two single tumors (extranodal) on opposite sides of the diaphragm. Two or more nodal areas above and below the diaphragm. All the primary intra-thoracic tumors (mediastinal, pleural, thymic). All extensive primary intra-abdominal disease, unresectable. All paraspinal or epidural tumors, regardless of other tumor site(s)." @default.
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- W2564518265 date "1985-01-01" @default.
- W2564518265 modified "2023-09-27" @default.
- W2564518265 title "based upon stage and immunopathologic subtype: Rationale and current results" @default.
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- W2564518265 hasPublicationYear "1985" @default.
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