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- W2564519474 abstract "A multi-age rat model was developed and utilized to examine potential age-dependent differences in drug-induced renal toxicity caused by cisplatin. Male Sprague-Dawley rats (10-, 25-, 40-, and 80-days-old) were dosed with 0, 1, 3 and 6 mg/kg i.p. cisplatin (cip). The high dose of cip (6 mg/kg) caused: decreased body weight (all ages); decreased kidney weight/body weight (80-days-old); moderate to severe renal lesions (tubular necrosis and apoptosis) (all ages except 25-days-old); significantly increased serum BUN and creatinine levels (80- and 40-days-old). This dose also caused increases in the urinary level of the renal biomarkers: kidney injury molecule-1 (Kim-1), renal papillary antigen-1 (RPA-1) and N-acetyl-beta-D-glucosaminidase (NAG) in 40- (72 hrs) and 80- (48 and 72 hrs) day-old rats; increases only in NAG and RPA-1 occurred in 25-day-old rats (72 hrs). Significant increases in the gene expression levels of 4 nephrotoxicity biomarkers (Kim-1, Spp1, Lcn2, Clu) were detected in the kidneys from all age groups (except for 25-days-old) treated with 6 mg/kg cip. In addition, similar gene expression levels were observed in 40- and 80-day-old rats given 3 mg/kg cip. Glucosuria and hydroxyprolinuria were detected on day 2 and 3 in 40- and 80-day-old rats. These findings indicate that certain biomarkers can help identify these age-related differences in susceptibility." @default.
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- W2564519474 date "2008-03-01" @default.
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- W2564519474 title "Age‐Related Differences in Cisplatin‐Induced Renal Toxicity in Rats" @default.
- W2564519474 doi "https://doi.org/10.1096/fasebj.22.1_supplement.917.7" @default.
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