FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564556500> ?p ?o ?g. }

• W2564556500 abstract "Studies in health care professional (HCPs) have demonstrated a high prevalence of dehydration, which has been linked with morphological brain changes as well as cognitive impairment in other groups. Moreover, many age-related pathophysiological changes result in increased susceptibility to fluid and electrolyte imbalance, rendering older adults vulnerable to dehydration which may be associated with poor outcome. This thesis investigates the prevalence of dehydration and impact on cognitive function amongst HCPs. It also investigates the prevalence of dehydration in hospitalised older adults and the association between dehydration, acute kidney injury (AKI) and clinical outcome. Hydration status and cognition were objectively assessed in nurses and doctors working on emergency medical and surgical wards. This study demonstrated that a significant proportion of HCPs were dehydrated at the start and end of their shifts and many were oliguric. The prevalence of dehydration varied with level of experience and speciality and was associated with short-term memory impairment. Using serum osmolality, the key regulated variable in fluid homeostasis as a measure of hydration status in hospitalised older adults, prospective assessment of 200 patients demonstrated that over a third had hyperosmolar dehydration (HD) at admission, two-thirds of which were dehydrated 48 hours later. Dehydration at admission was independently associated with a six-fold increase in 30-day mortality. Subsequent retrospective assessment of 32,980 hospitalised older adults demonstrated that dehydration was diagnosed clinically in 8.9% of patients and was independently associated with a two fold increase in mortality. Nearly half of those dehydrated had a concomitant diagnosis of AKI and the median length of hospital stay (LOS) was nearly three times greater than those without the condition. Despite the widespread use of serum osmolality in human physiology studies, it is rarely used clinically to assess hydration. Analysis of published equations estimating osmolality, demonstrated that an equation by Khajuria and Krahn was 90% sensitivity and 97% specificity at diagnosing hyperosmolar dehydration. Using this equation, we demonstrated that 27.2% of 6632 older adults had HD at admission to hospital and the risk of developing AKI 12-24 hours after admission in these patients was five times those euhydrated at admission. Moreover, the 30-day mortality was nearly twice that of euhydrated patients, independent of key confounders. The median LOS in dehydrated patients was almost double.This work has highlighted the need to educate both patients and HCPs on the importance of hydration. Further work is required to prospectively assess the use of serum osmolality as a predictor of dehydration, AKI and outcomes. Given that hydration and nutrition are the hallmarks of compassionate care, there is clear room for improvement with findings from this thesis suggesting the need for further investigation and intervention in both community and hospital settings." @default.
• W2564556500 created "2017-01-06" @default.
• W2564556500 creator A5008352299 @default.
• W2564556500 date "2016-12-16" @default.
• W2564556500 modified "2023-09-24" @default.
• W2564556500 title "Hydration, kidney injury and clinical outcome" @default.
• W2564556500 hasPublicationYear "2016" @default.
• W2564556500 type Work @default.
• W2564556500 sameAs 2564556500 @default.
• W2564556500 citedByCount "0" @default.
• W2564556500 crossrefType "dissertation" @default.
• W2564556500 hasAuthorship W2564556500A5008352299 @default.
• W2564556500 hasConcept C126322002 @default.
• W2564556500 hasConcept C177713679 @default.
• W2564556500 hasConcept C185592680 @default.
• W2564556500 hasConcept C2778769901 @default.
• W2564556500 hasConcept C2779384505 @default.
• W2564556500 hasConcept C2780472472 @default.
• W2564556500 hasConcept C3017845882 @default.
• W2564556500 hasConcept C55493867 @default.
• W2564556500 hasConcept C71924100 @default.
• W2564556500 hasConceptScore W2564556500C126322002 @default.
• W2564556500 hasConceptScore W2564556500C177713679 @default.
• W2564556500 hasConceptScore W2564556500C185592680 @default.
• W2564556500 hasConceptScore W2564556500C2778769901 @default.
• W2564556500 hasConceptScore W2564556500C2779384505 @default.
• W2564556500 hasConceptScore W2564556500C2780472472 @default.
• W2564556500 hasConceptScore W2564556500C3017845882 @default.
• W2564556500 hasConceptScore W2564556500C55493867 @default.
• W2564556500 hasConceptScore W2564556500C71924100 @default.
• W2564556500 hasLocation W25645565001 @default.
• W2564556500 hasOpenAccess W2564556500 @default.
• W2564556500 hasPrimaryLocation W25645565001 @default.
• W2564556500 hasRelatedWork W1174523014 @default.
• W2564556500 hasRelatedWork W1584203674 @default.
• W2564556500 hasRelatedWork W2019613528 @default.
• W2564556500 hasRelatedWork W2068277038 @default.
• W2564556500 hasRelatedWork W2116445958 @default.
• W2564556500 hasRelatedWork W2122578365 @default.
• W2564556500 hasRelatedWork W2135249714 @default.
• W2564556500 hasRelatedWork W2138517260 @default.
• W2564556500 hasRelatedWork W2413930886 @default.
• W2564556500 hasRelatedWork W2567694500 @default.
• W2564556500 hasRelatedWork W2793180165 @default.
• W2564556500 hasRelatedWork W2887283487 @default.
• W2564556500 hasRelatedWork W2991120335 @default.
• W2564556500 hasRelatedWork W3027395892 @default.
• W2564556500 hasRelatedWork W3125965714 @default.
• W2564556500 hasRelatedWork W3166037346 @default.
• W2564556500 hasRelatedWork W3184536981 @default.
• W2564556500 hasRelatedWork W3194208543 @default.
• W2564556500 hasRelatedWork W3206990928 @default.
• W2564556500 hasRelatedWork W2035432825 @default.
• W2564556500 isParatext "false" @default.
• W2564556500 isRetracted "false" @default.
• W2564556500 magId "2564556500" @default.
• W2564556500 workType "dissertation" @default.