Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564577428> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2564577428 endingPage "e21160" @default.
- W2564577428 startingPage "e21160" @default.
- W2564577428 abstract "e21160 Background: Ki67 has been used as a prognostic biomarker of oncologic outcomes after treatment of several malignant tumors. The current study assessed the long term predictive of Ki67 positive tumor cells on tissue adherent to multitined electrodes, on local tumor progression (LTP) and overall survival (OS) after radiofrequency ablation (RFA) of liver tumors. Methods: Examination of tissue adherent to electrodes after RF ablation of liver malignancies was performed looking for proliferation (Ki-67) and apoptosis (caspase-3) markers. Clinical and technical information was collected from a hepatobiliary database. In patients with tumors smaller than 5cm in diameter a retrospective review of medical records and imaging was performed. Local Tumor Progression Free Survival (LPFS) and overall survival (OS) probabilities were estimated with the Kaplan-Meier methodology and compared using the log-rank test. Multivariate analysis was performed to assess the effect of tumor size, primary pathology, and post ablation tissue characteristics on LPFS and OS. Results: Sixty-eight ablated tumors were identified in 63 patients. Post ablation tissue examinations classified 55 specimens as completely ablated/ coagulation necrosis (CN) and 13 as viable tumor (V) containing tumor cells positive for Ki-67. Mean tumor size was larger in the V (3.4 cm) than in the CN (2.5 cm) (P = .017). Ninety-two percent of patients with V and 58% with CN have died within the median follow-up of 63 months. The 1-, 3-, and 5-year LPFS and OS probabilities were significantly prolonged in the CN group (table). Conclusions: Viable tumor cells (Ki-67+) on the electrode after RFA of hepatic tumors is an independent predictor of local tumor progression free and overall survival on multivariant analysis. Survival V CN year n=13 n=55 P LPFS 1 8% 79% 3 8% 47% .001 5 8% 47% OS 1 92% 92% 3 25% 59% .032 5 8% 33%" @default.
- W2564577428 created "2017-01-06" @default.
- W2564577428 creator A5008722966 @default.
- W2564577428 creator A5010847388 @default.
- W2564577428 creator A5016615488 @default.
- W2564577428 creator A5020625278 @default.
- W2564577428 creator A5022378712 @default.
- W2564577428 creator A5024318857 @default.
- W2564577428 creator A5044395860 @default.
- W2564577428 creator A5052590842 @default.
- W2564577428 creator A5061252101 @default.
- W2564577428 creator A5078241870 @default.
- W2564577428 creator A5088096313 @default.
- W2564577428 date "2011-05-20" @default.
- W2564577428 modified "2023-09-26" @default.
- W2564577428 title "Ki67 as a prognostic biomarker of 5-year oncologic outcomes following ablation of liver malignancies." @default.
- W2564577428 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e21160" @default.
- W2564577428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28022712" @default.
- W2564577428 hasPublicationYear "2011" @default.
- W2564577428 type Work @default.
- W2564577428 sameAs 2564577428 @default.
- W2564577428 citedByCount "0" @default.
- W2564577428 crossrefType "journal-article" @default.
- W2564577428 hasAuthorship W2564577428A5008722966 @default.
- W2564577428 hasAuthorship W2564577428A5010847388 @default.
- W2564577428 hasAuthorship W2564577428A5016615488 @default.
- W2564577428 hasAuthorship W2564577428A5020625278 @default.
- W2564577428 hasAuthorship W2564577428A5022378712 @default.
- W2564577428 hasAuthorship W2564577428A5024318857 @default.
- W2564577428 hasAuthorship W2564577428A5044395860 @default.
- W2564577428 hasAuthorship W2564577428A5052590842 @default.
- W2564577428 hasAuthorship W2564577428A5061252101 @default.
- W2564577428 hasAuthorship W2564577428A5078241870 @default.
- W2564577428 hasAuthorship W2564577428A5088096313 @default.
- W2564577428 hasConcept C10515644 @default.
- W2564577428 hasConcept C121608353 @default.
- W2564577428 hasConcept C126322002 @default.
- W2564577428 hasConcept C142724271 @default.
- W2564577428 hasConcept C143998085 @default.
- W2564577428 hasConcept C185592680 @default.
- W2564577428 hasConcept C21613296 @default.
- W2564577428 hasConcept C2777377203 @default.
- W2564577428 hasConcept C2778902805 @default.
- W2564577428 hasConcept C2779256057 @default.
- W2564577428 hasConcept C2781197716 @default.
- W2564577428 hasConcept C55493867 @default.
- W2564577428 hasConcept C66339696 @default.
- W2564577428 hasConcept C71924100 @default.
- W2564577428 hasConcept C90924648 @default.
- W2564577428 hasConceptScore W2564577428C10515644 @default.
- W2564577428 hasConceptScore W2564577428C121608353 @default.
- W2564577428 hasConceptScore W2564577428C126322002 @default.
- W2564577428 hasConceptScore W2564577428C142724271 @default.
- W2564577428 hasConceptScore W2564577428C143998085 @default.
- W2564577428 hasConceptScore W2564577428C185592680 @default.
- W2564577428 hasConceptScore W2564577428C21613296 @default.
- W2564577428 hasConceptScore W2564577428C2777377203 @default.
- W2564577428 hasConceptScore W2564577428C2778902805 @default.
- W2564577428 hasConceptScore W2564577428C2779256057 @default.
- W2564577428 hasConceptScore W2564577428C2781197716 @default.
- W2564577428 hasConceptScore W2564577428C55493867 @default.
- W2564577428 hasConceptScore W2564577428C66339696 @default.
- W2564577428 hasConceptScore W2564577428C71924100 @default.
- W2564577428 hasConceptScore W2564577428C90924648 @default.
- W2564577428 hasIssue "15_suppl" @default.
- W2564577428 hasLocation W25645774281 @default.
- W2564577428 hasOpenAccess W2564577428 @default.
- W2564577428 hasPrimaryLocation W25645774281 @default.
- W2564577428 hasRelatedWork W2041083782 @default.
- W2564577428 hasRelatedWork W2339322929 @default.
- W2564577428 hasRelatedWork W2348226720 @default.
- W2564577428 hasRelatedWork W2360341076 @default.
- W2564577428 hasRelatedWork W2365005442 @default.
- W2564577428 hasRelatedWork W2501579238 @default.
- W2564577428 hasRelatedWork W2977520799 @default.
- W2564577428 hasRelatedWork W3087392113 @default.
- W2564577428 hasRelatedWork W3140130525 @default.
- W2564577428 hasRelatedWork W85908649 @default.
- W2564577428 hasVolume "29" @default.
- W2564577428 isParatext "false" @default.
- W2564577428 isRetracted "false" @default.
- W2564577428 magId "2564577428" @default.
- W2564577428 workType "article" @default.