FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564577981> ?p ?o ?g. }

• W2564577981 abstract "Abstract The assessment of neutrophil dysplasia is very useful for the diagnosis of the Myelodysplastic Syndromes (MDS), and the common accepted method for that purpose is the microscopic examination of blood and/or bone marrow smears. But one of the problems in the daily practice, is the lack of reproducibility between the different observers, and technical problems, like the time of the stain, quality of the stain, including quality of the reagents and time of the smear after blood draw. The last advanced hematology instruments, like the Coulter LH750®, provide, together with the report of the WBC differential, automated morphological data about some of the different types of leukocytes: Neutrophils, Lymphocytes, Monocytes and Eosinophils. This Research Data (RPD), gives information about the Mean and Standard deviation of the Cell Volume, Conductivity, and Scatter using a technology called VCS technology. We have collected 53 patients affected of MDS, and 18 affected with Chronic Myelomonocytic Leukemia (CMML) and we compared the leukocyte automated leukocyte morphological data (WRPD) of the patients with the WRPD of 59 normal persons. One of the modifications in the actual WHO classifications is the differentiation between CMML with or without dysplasia and Mylodysplastic Syndromes with or without trilineage dysplasia, that also affect the prognosis. We have checked also these new parameters for this purpose. The results have shown: The Mean Neutrophil Scatter (MNES) and Mean Neutrophil Conductivity (MNEC) was significant lower in the MDS compared with the normal (both p&lt;0.0001) the ROC curve analysis show a Sensitivity of 71.8% with a Specificity of 86.4% and a cut off of &lt; 139.3 for the MNESand a Sensitivity of 70.4% with a Specificity of 76.3% and a cut off of &lt; 150.9 for the MNECdetecting MDS. For the differentiation of MDS and CMML with or without dysplasia the results have shown a significant difference p = 0.02 in the MNESbetween CMML-1 and CMML-2 and MDS with or without trilineage dysplasia. The changes in the Neutrophil Scatter and in the Neutrophil Conductivity (lower values) correlates with the dysplastic feature neutrophil degranulation observed in the microscope. Conclussion: MNEC and MNES seem to be useful in the detection of neutrophil dysplasia and helpful in the diagnosis of MDS. Figure Figure" @default.
• W2564577981 created "2017-01-06" @default.
• W2564577981 creator A5006695997 @default.
• W2564577981 creator A5015986995 @default.
• W2564577981 creator A5017703525 @default.
• W2564577981 creator A5035042471 @default.
• W2564577981 creator A5068745310 @default.
• W2564577981 creator A5083851546 @default.
• W2564577981 date "2006-11-16" @default.
• W2564577981 modified "2023-09-26" @default.
• W2564577981 title "Automated Neutrophil Morphology and Its Utility in the Assessment of Neutrophil Dysplasia and in the Diagnosis of Myelodysplastic Syndromes." @default.
• W2564577981 doi "https://doi.org/10.1182/blood.v108.11.4870.4870" @default.
• W2564577981 hasPublicationYear "2006" @default.
• W2564577981 type Work @default.
• W2564577981 sameAs 2564577981 @default.
• W2564577981 citedByCount "3" @default.
• W2564577981 countsByYear W25645779812023 @default.
• W2564577981 crossrefType "journal-article" @default.
• W2564577981 hasAuthorship W2564577981A5006695997 @default.
• W2564577981 hasAuthorship W2564577981A5015986995 @default.
• W2564577981 hasAuthorship W2564577981A5017703525 @default.
• W2564577981 hasAuthorship W2564577981A5035042471 @default.
• W2564577981 hasAuthorship W2564577981A5068745310 @default.
• W2564577981 hasAuthorship W2564577981A5083851546 @default.
• W2564577981 hasConcept C126322002 @default.
• W2564577981 hasConcept C142724271 @default.
• W2564577981 hasConcept C2775894508 @default.
• W2564577981 hasConcept C2777928532 @default.
• W2564577981 hasConcept C2780007613 @default.
• W2564577981 hasConcept C2780817109 @default.
• W2564577981 hasConcept C2781294515 @default.
• W2564577981 hasConcept C71924100 @default.
• W2564577981 hasConcept C74864618 @default.
• W2564577981 hasConceptScore W2564577981C126322002 @default.
• W2564577981 hasConceptScore W2564577981C142724271 @default.
• W2564577981 hasConceptScore W2564577981C2775894508 @default.
• W2564577981 hasConceptScore W2564577981C2777928532 @default.
• W2564577981 hasConceptScore W2564577981C2780007613 @default.
• W2564577981 hasConceptScore W2564577981C2780817109 @default.
• W2564577981 hasConceptScore W2564577981C2781294515 @default.
• W2564577981 hasConceptScore W2564577981C71924100 @default.
• W2564577981 hasConceptScore W2564577981C74864618 @default.
• W2564577981 hasLocation W25645779811 @default.
• W2564577981 hasOpenAccess W2564577981 @default.
• W2564577981 hasPrimaryLocation W25645779811 @default.
• W2564577981 hasRelatedWork W1979879346 @default.
• W2564577981 hasRelatedWork W2009854240 @default.
• W2564577981 hasRelatedWork W2020385828 @default.
• W2564577981 hasRelatedWork W2042303179 @default.
• W2564577981 hasRelatedWork W2133721150 @default.
• W2564577981 hasRelatedWork W2312863491 @default.
• W2564577981 hasRelatedWork W2402716478 @default.
• W2564577981 hasRelatedWork W2564577981 @default.
• W2564577981 hasRelatedWork W3030694975 @default.
• W2564577981 hasRelatedWork W87538008 @default.
• W2564577981 isParatext "false" @default.
• W2564577981 isRetracted "false" @default.
• W2564577981 magId "2564577981" @default.
• W2564577981 workType "article" @default.