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- W2564624675 abstract "Background: Omalizumab (OMA) is marketed for severe asthma patients allergic to perennial allergens. Our purpose was to investigate whether OMA is also as effective in severe asthma due to seasonal allergens.Method: Population: 30 patients with oral corticosteroid-dependent asthma (receiving 4 mg of methyl-prednisolone (MP) per day ≥ 1 year or boosters of MP equivalent to a mean daily dose of 4 mg of MP). For each patient with asthma due to seasonal allergens, we recruited the next two consecutive patients with asthma due to perennial allergens. Protocol: a) OMA dose was calculated according to the dosing table; b) patients were considered responders or non-responders after six months of treatment with OMA; c) the dose of oral MP was tapered at a rate of 2 mg every two weeks depending on tolerance; f) at every monthly visit, forced spirometry (S) was performed and the accumulated monthly MP dose was calculated.Results: At entry there were no differences in gender, body mass index or obesity, monthly dose of MP or S between groups (Perennial: FVC: 76% (20); FEV1: 62% (22); Seasonal: FVC: 79% (12); FEV1:70% (16)).Follow-up: One patient in each group was considered a non-responder; S did not deteriorate in either group. There was a significant intragroup decrease in MP consumption (p<0.001) but no differences were detected in the intergroup comparison (P=0.958).Conclusions: 1) In these cohorts of patients, OMA seemed to offer the same clinical benefits independently of whether the asthma was caused by a seasonal or perennial allergen; 2) The patient's drop-out rate (10-20%) was expected in the light of previous literature reports." @default.
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- W2564624675 date "2015-09-01" @default.
- W2564624675 modified "2023-10-02" @default.
- W2564624675 title "Omalizumab is equally effective in persistent allergic oral corticosteroid-dependent asthma whether due to seasonal allergens or to perennial allergens" @default.
- W2564624675 doi "https://doi.org/10.1183/13993003.congress-2015.pa1097" @default.
- W2564624675 hasPublicationYear "2015" @default.
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