Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564639536> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2564639536 abstract "Background: Chronic airway diseases like asthma and chronic obstructive pulmonary disease (COPD) are associated with abnormal mucosal responses to inhaled materials. In COPD, while immunoglobulin (Ig)A synthesis is up-regulated, expression of pIgR/SC (polymeric immunoglobulin receptor/secretory component) is markedly decreased, presumably resulting in impaired defense mechanisms against pathogens. Objectives: We explored IgA production and transport in human severe asthma and its potential regulation by the Th2/IL-13 pathway. Methods: Bronchial biopsies and in vitro-reconstituted bronchial epithelium from these biopsies, re-differentiated upon air-liquid interface (ALI-HBEC), were assayed for pIgR expression and regulation by IL-13. Results: We identified a downregulation of IgA1 and IgA2 mRNA synthesis in biopsies from severe asthma vs controls (p=0.002 for IgA1 and p=0.034 for IgA2). A downregulation of pIgR protein (but not mRNA) was also observed. IL-13 stimulation of ALI-HBEC induced, besides eotaxin-3 and periostin, a downregulation of SC release while pIgR mRNA levels were not affected, further suggesting post-transcriptional regulation of pIgR by IL-13. Conclusion: Altogether, this study shows impaired lung IgA responses in severe asthma and identifies IL-13 as potential mechanism, suggesting that targeting this cytokine could restore frontline IgA-mediated lung defence in chronic Th2-mediated airway disease." @default.
- W2564639536 created "2017-01-06" @default.
- W2564639536 creator A5000408718 @default.
- W2564639536 creator A5011053424 @default.
- W2564639536 creator A5011373045 @default.
- W2564639536 creator A5023940630 @default.
- W2564639536 creator A5026139034 @default.
- W2564639536 creator A5032614922 @default.
- W2564639536 creator A5039129582 @default.
- W2564639536 creator A5047526745 @default.
- W2564639536 creator A5063249079 @default.
- W2564639536 creator A5076809475 @default.
- W2564639536 creator A5087920627 @default.
- W2564639536 creator A5088744103 @default.
- W2564639536 date "2015-09-01" @default.
- W2564639536 modified "2023-10-05" @default.
- W2564639536 title "Impaired synthesis and transport of immunoglobulin A in severe asthma: Role of IL-13" @default.
- W2564639536 doi "https://doi.org/10.1183/13993003.congress-2015.pa5104" @default.
- W2564639536 hasPublicationYear "2015" @default.
- W2564639536 type Work @default.
- W2564639536 sameAs 2564639536 @default.
- W2564639536 citedByCount "1" @default.
- W2564639536 countsByYear W25646395362018 @default.
- W2564639536 crossrefType "proceedings-article" @default.
- W2564639536 hasAuthorship W2564639536A5000408718 @default.
- W2564639536 hasAuthorship W2564639536A5011053424 @default.
- W2564639536 hasAuthorship W2564639536A5011373045 @default.
- W2564639536 hasAuthorship W2564639536A5023940630 @default.
- W2564639536 hasAuthorship W2564639536A5026139034 @default.
- W2564639536 hasAuthorship W2564639536A5032614922 @default.
- W2564639536 hasAuthorship W2564639536A5039129582 @default.
- W2564639536 hasAuthorship W2564639536A5047526745 @default.
- W2564639536 hasAuthorship W2564639536A5063249079 @default.
- W2564639536 hasAuthorship W2564639536A5076809475 @default.
- W2564639536 hasAuthorship W2564639536A5087920627 @default.
- W2564639536 hasAuthorship W2564639536A5088744103 @default.
- W2564639536 hasConcept C141105273 @default.
- W2564639536 hasConcept C159654299 @default.
- W2564639536 hasConcept C203014093 @default.
- W2564639536 hasConcept C2776042228 @default.
- W2564639536 hasConcept C71924100 @default.
- W2564639536 hasConceptScore W2564639536C141105273 @default.
- W2564639536 hasConceptScore W2564639536C159654299 @default.
- W2564639536 hasConceptScore W2564639536C203014093 @default.
- W2564639536 hasConceptScore W2564639536C2776042228 @default.
- W2564639536 hasConceptScore W2564639536C71924100 @default.
- W2564639536 hasLocation W25646395361 @default.
- W2564639536 hasOpenAccess W2564639536 @default.
- W2564639536 hasPrimaryLocation W25646395361 @default.
- W2564639536 hasRelatedWork W1489227157 @default.
- W2564639536 hasRelatedWork W1988863520 @default.
- W2564639536 hasRelatedWork W2028271463 @default.
- W2564639536 hasRelatedWork W2087982072 @default.
- W2564639536 hasRelatedWork W2114202994 @default.
- W2564639536 hasRelatedWork W2405551697 @default.
- W2564639536 hasRelatedWork W2951760377 @default.
- W2564639536 hasRelatedWork W3119564648 @default.
- W2564639536 hasRelatedWork W4322724676 @default.
- W2564639536 hasRelatedWork W44538298 @default.
- W2564639536 isParatext "false" @default.
- W2564639536 isRetracted "false" @default.
- W2564639536 magId "2564639536" @default.
- W2564639536 workType "article" @default.