FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564650850> ?p ?o ?g. }

• W2564650850 endingPage "26" @default.
• W2564650850 startingPage "21" @default.
• W2564650850 abstract "The molecular mechanisms underlying the cellular uptake of long-chain fatty acids and the regulation of this process have been elucidated in appreciable detail in the last decades. Two main players in this field, each discovered in the early 1990s, are (i) a membrane-associated protein first identified in adipose ('fat') tissue and referred to as putative fatty acid translocase (FAT)/CD36 (now officially designated as SR-B2) which facilitates the transport of fatty acids across the plasma membrane, and (ii) the family of transcription factors designated peroxisome proliferator-activated receptors (PPARα, PPARγ, and PPARβ/δ) for which fatty acids and fatty acid metabolites are the preferred ligand. CD36/SR-B2 is the predominant membrane protein involved in fatty acid uptake into intestinal enterocytes, adipocytes and cardiac and skeletal myocytes. The rate of cellular fatty acid uptake is regulated by the subcellular vesicular recycling of CD36/SR-B2 from endosomes to the plasma membrane. Fatty acid-induced activation of PPARs results in the upregulation of the expression of genes encoding various proteins and enzymes involved in cellular fatty acid utilization. Both CD36/SR-B2 and the PPARs have been implicated in the derangements in fatty acid and lipid metabolism occurring with the development of pathophysiological conditions, such as high fat diet-induced insulin resistance and diabetic cardiomyopathy, and have been suggested as targets for metabolic intervention. In this brief review we discuss the discovery and current understanding of both CD36/SR-B2 and the PPARs in metabolic homeostasis." @default.
• W2564650850 created "2017-01-06" @default.
• W2564650850 creator A5008541293 @default.
• W2564650850 creator A5072123276 @default.
• W2564650850 date "2017-05-01" @default.
• W2564650850 modified "2023-10-02" @default.
• W2564650850 title "From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake" @default.
• W2564650850 cites W1512516272 @default.
• W2564650850 cites W1547032503 @default.
• W2564650850 cites W1574064714 @default.
• W2564650850 cites W1599923603 @default.
• W2564650850 cites W1851358861 @default.
• W2564650850 cites W1868137283 @default.
• W2564650850 cites W1974974158 @default.
• W2564650850 cites W1978551433 @default.
• W2564650850 cites W1984150991 @default.
• W2564650850 cites W1990481363 @default.
• W2564650850 cites W1995626771 @default.
• W2564650850 cites W2001050822 @default.
• W2564650850 cites W2001496481 @default.
• W2564650850 cites W2003859756 @default.
• W2564650850 cites W2003927905 @default.
• W2564650850 cites W2011178652 @default.
• W2564650850 cites W2012071760 @default.
• W2564650850 cites W2013859761 @default.
• W2564650850 cites W2015385218 @default.
• W2564650850 cites W2016651319 @default.
• W2564650850 cites W2026527234 @default.
• W2564650850 cites W2030330182 @default.
• W2564650850 cites W2038724164 @default.
• W2564650850 cites W2040197119 @default.
• W2564650850 cites W2057521072 @default.
• W2564650850 cites W2058194924 @default.
• W2564650850 cites W2074045859 @default.
• W2564650850 cites W2080273261 @default.
• W2564650850 cites W2091191922 @default.
• W2564650850 cites W2092435249 @default.
• W2564650850 cites W2098372964 @default.
• W2564650850 cites W2099635702 @default.
• W2564650850 cites W2105604211 @default.
• W2564650850 cites W2107542389 @default.
• W2564650850 cites W2115163604 @default.
• W2564650850 cites W2119016586 @default.
• W2564650850 cites W2119087377 @default.
• W2564650850 cites W2127039193 @default.
• W2564650850 cites W2130508617 @default.
• W2564650850 cites W2134270245 @default.
• W2564650850 cites W2136943950 @default.
• W2564650850 cites W2142796533 @default.
• W2564650850 cites W2145388099 @default.
• W2564650850 cites W2147073885 @default.
• W2564650850 cites W2154074778 @default.
• W2564650850 cites W2154607830 @default.
• W2564650850 cites W2158592541 @default.
• W2564650850 cites W2160476964 @default.
• W2564650850 cites W2172003877 @default.
• W2564650850 cites W2180182740 @default.
• W2564650850 cites W2284080609 @default.
• W2564650850 cites W2301570128 @default.
• W2564650850 cites W2310847573 @default.
• W2564650850 cites W2330012690 @default.
• W2564650850 cites W2335788856 @default.
• W2564650850 cites W2338757077 @default.
• W2564650850 cites W2463474031 @default.
• W2564650850 cites W2519329187 @default.
• W2564650850 cites W4240750757 @default.
• W2564650850 cites W4253244719 @default.
• W2564650850 cites W4255514122 @default.
• W2564650850 doi "https://doi.org/10.1016/j.biochi.2016.12.007" @default.
• W2564650850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28013071" @default.
• W2564650850 hasPublicationYear "2017" @default.
• W2564650850 type Work @default.
• W2564650850 sameAs 2564650850 @default.
• W2564650850 citedByCount "142" @default.
• W2564650850 countsByYear W25646508502017 @default.
• W2564650850 countsByYear W25646508502018 @default.
• W2564650850 countsByYear W25646508502019 @default.
• W2564650850 countsByYear W25646508502020 @default.
• W2564650850 countsByYear W25646508502021 @default.
• W2564650850 countsByYear W25646508502022 @default.
• W2564650850 countsByYear W25646508502023 @default.
• W2564650850 crossrefType "journal-article" @default.
• W2564650850 hasAuthorship W2564650850A5008541293 @default.
• W2564650850 hasAuthorship W2564650850A5072123276 @default.
• W2564650850 hasBestOaLocation W25646508502 @default.
• W2564650850 hasConcept C126322002 @default.
• W2564650850 hasConcept C127078168 @default.
• W2564650850 hasConcept C134018914 @default.
• W2564650850 hasConcept C170493617 @default.
• W2564650850 hasConcept C171089720 @default.
• W2564650850 hasConcept C187345961 @default.
• W2564650850 hasConcept C24972589 @default.
• W2564650850 hasConcept C2776991927 @default.
• W2564650850 hasConcept C2777391703 @default.
• W2564650850 hasConcept C2778938600 @default.
• W2564650850 hasConcept C2779306644 @default.
• W2564650850 hasConcept C2779828298 @default.
• W2564650850 hasConcept C32670627 @default.

• next