FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564682719> ?p ?o ?g. }

• W2564682719 endingPage "e0161920" @default.
• W2564682719 startingPage "e0161920" @default.
• W2564682719 abstract "Background We evaluated plasma samples HIV-infected individuals with different phenotypic profile among five HIV-infected elite controllers and five rapid progressors after recent HIV infection and one year later and from 10 individuals subjected to antiretroviral therapy, five of whom were immunological non-responders (INR), before and after one year of antiretroviral treatment compared to 175 samples from HIV-negative patients. A targeted quantitative tandem mass spectrometry metabolomics approach was used in order to determine plasma metabolomics biosignature that may relate to HIV infection, pace of HIV disease progression, and immunological response to treatment. Results Twenty-five unique metabolites were identified, including five metabolites that could distinguish rapid progressors and INRs at baseline. Severe deregulation in acylcarnitine and sphingomyelin metabolism compatible with mitochondrial deficiencies was observed. β-oxidation and sphingosine‐1‐phosphate-phosphatase-1 activity were down-regulated, whereas acyl-alkyl-containing phosphatidylcholines and alkylglyceronephosphate synthase levels were elevated in INRs. Evidence that elite controllers harbor an inborn error of metabolism (late-onset multiple acyl-coenzyme A dehydrogenase deficiency [MADD]) was detected. Conclusions Blood-based markers from metabolomics show a very high accuracy of discriminating HIV infection between varieties of controls and have the ability to predict rapid disease progression or poor antiretroviral immunological response. These metabolites can be used as biomarkers of HIV natural evolution or treatment response and provide insight into the mechanisms of the disease." @default.
• W2564682719 created "2017-01-06" @default.
• W2564682719 creator A5011904763 @default.
• W2564682719 creator A5046968397 @default.
• W2564682719 creator A5058321366 @default.
• W2564682719 creator A5065077331 @default.
• W2564682719 creator A5067072926 @default.
• W2564682719 creator A5079615499 @default.
• W2564682719 creator A5088124782 @default.
• W2564682719 date "2016-12-12" @default.
• W2564682719 modified "2023-10-18" @default.
• W2564682719 title "Plasma Metabolomics Biosignature According to HIV Stage of Infection, Pace of Disease Progression, Viremia Level and Immunological Response to Treatment" @default.
• W2564682719 cites W1504600256 @default.
• W2564682719 cites W1571252195 @default.
• W2564682719 cites W1967180851 @default.
• W2564682719 cites W1970640392 @default.
• W2564682719 cites W1976714959 @default.
• W2564682719 cites W1989987423 @default.
• W2564682719 cites W1992112534 @default.
• W2564682719 cites W1992666436 @default.
• W2564682719 cites W1994877856 @default.
• W2564682719 cites W2002301651 @default.
• W2564682719 cites W2002874098 @default.
• W2564682719 cites W2016445640 @default.
• W2564682719 cites W2019209482 @default.
• W2564682719 cites W2019336943 @default.
• W2564682719 cites W2036691064 @default.
• W2564682719 cites W2040538344 @default.
• W2564682719 cites W2067600328 @default.
• W2564682719 cites W2073123390 @default.
• W2564682719 cites W2076027168 @default.
• W2564682719 cites W2079910432 @default.
• W2564682719 cites W2093938047 @default.
• W2564682719 cites W2095317434 @default.
• W2564682719 cites W2096380205 @default.
• W2564682719 cites W2096482492 @default.
• W2564682719 cites W2098014021 @default.
• W2564682719 cites W2108117437 @default.
• W2564682719 cites W2116549010 @default.
• W2564682719 cites W2117524242 @default.
• W2564682719 cites W2117782909 @default.
• W2564682719 cites W2132567665 @default.
• W2564682719 cites W2135607659 @default.
• W2564682719 cites W2141948503 @default.
• W2564682719 cites W2155680682 @default.
• W2564682719 cites W2162783323 @default.
• W2564682719 cites W2166014072 @default.
• W2564682719 cites W2167717154 @default.
• W2564682719 cites W2172198911 @default.
• W2564682719 cites W4234769079 @default.
• W2564682719 doi "https://doi.org/10.1371/journal.pone.0161920" @default.
• W2564682719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5325603" @default.
• W2564682719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28235085" @default.
• W2564682719 hasPublicationYear "2016" @default.
• W2564682719 type Work @default.
• W2564682719 sameAs 2564682719 @default.
• W2564682719 citedByCount "38" @default.
• W2564682719 countsByYear W25646827192017 @default.
• W2564682719 countsByYear W25646827192018 @default.
• W2564682719 countsByYear W25646827192019 @default.
• W2564682719 countsByYear W25646827192020 @default.
• W2564682719 countsByYear W25646827192021 @default.
• W2564682719 countsByYear W25646827192022 @default.
• W2564682719 countsByYear W25646827192023 @default.
• W2564682719 crossrefType "journal-article" @default.
• W2564682719 hasAuthorship W2564682719A5011904763 @default.
• W2564682719 hasAuthorship W2564682719A5046968397 @default.
• W2564682719 hasAuthorship W2564682719A5058321366 @default.
• W2564682719 hasAuthorship W2564682719A5065077331 @default.
• W2564682719 hasAuthorship W2564682719A5067072926 @default.
• W2564682719 hasAuthorship W2564682719A5079615499 @default.
• W2564682719 hasAuthorship W2564682719A5088124782 @default.
• W2564682719 hasBestOaLocation W25646827191 @default.
• W2564682719 hasConcept C126322002 @default.
• W2564682719 hasConcept C142462285 @default.
• W2564682719 hasConcept C203014093 @default.
• W2564682719 hasConcept C21565614 @default.
• W2564682719 hasConcept C2776185481 @default.
• W2564682719 hasConcept C2779134260 @default.
• W2564682719 hasConcept C3013748606 @default.
• W2564682719 hasConcept C60644358 @default.
• W2564682719 hasConcept C71924100 @default.
• W2564682719 hasConcept C86803240 @default.
• W2564682719 hasConceptScore W2564682719C126322002 @default.
• W2564682719 hasConceptScore W2564682719C142462285 @default.
• W2564682719 hasConceptScore W2564682719C203014093 @default.
• W2564682719 hasConceptScore W2564682719C21565614 @default.
• W2564682719 hasConceptScore W2564682719C2776185481 @default.
• W2564682719 hasConceptScore W2564682719C2779134260 @default.
• W2564682719 hasConceptScore W2564682719C3013748606 @default.
• W2564682719 hasConceptScore W2564682719C60644358 @default.
• W2564682719 hasConceptScore W2564682719C71924100 @default.
• W2564682719 hasConceptScore W2564682719C86803240 @default.
• W2564682719 hasFunder F4320320997 @default.
• W2564682719 hasIssue "12" @default.
• W2564682719 hasLocation W25646827191 @default.
• W2564682719 hasLocation W25646827192 @default.
• W2564682719 hasLocation W25646827193 @default.

• next