FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564683775> ?p ?o ?g. }

• W2564683775 endingPage "2289" @default.
• W2564683775 startingPage "2280" @default.
• W2564683775 abstract "Background: Aberrant methylation of CpG islands in tumor cells in promoter regions is a critical event in non-small cell lung carcinoma (NSCLC) tumorigenesis and can be a potential diagnostic biomarker for NSCLC patients. The present study systemically and quantitatively reviewed the diagnostic ability of CDH13 methylation in NSCLC as well as in its subsets. Eligible studies were identified through searching PubMed, Web of Science, Cochrane Library and Embase. The pooled odds of CDH13 promoter methylation in lung cancer tissues versus normal controls were calculated by meta-analysis method. Simultaneously, four independent DNA methylation datasets of NSCLC from TCGA and GEO database were downloaded and analyzed to validate the results from meta-analysis. Results: Thirteen studies, including 1850 samples were included in this meta-analysis. The pooled odds ratio of CDH13 promoter methylation in cancer tissues was 7.41 (95% CI: 5.34 to 10.29, P < 0.00001) compared with that in controls under fixed-effect model. In validation stage, 126 paired samples from TCGA were analyzed and 5 out of the 6 CpG sites in the CpG island of CDH13 were significantly hypermethylated in lung adenocarcinoma tissues but none of the 6 CpG sites was hypermethylated in squamous cell carcinoma tissues. Concordantly, the results from other three datasets, which were subsequently obtained from GEO database consisting of 568 tumors and 256 normal tissues, also consisted with those from TCGA dataset. Conclusion: The pooled data showed that the methylation status of the CDH13 promoter is strongly associated with lung adenocarcinoma. The CDH13 methylation status could be a promising diagnostic biomarker for diagnosis of lung adenocarcinoma." @default.
• W2564683775 created "2017-01-06" @default.
• W2564683775 creator A5007806931 @default.
• W2564683775 creator A5021097559 @default.
• W2564683775 creator A5021725931 @default.
• W2564683775 creator A5033286474 @default.
• W2564683775 creator A5042534727 @default.
• W2564683775 creator A5050842690 @default.
• W2564683775 creator A5051169949 @default.
• W2564683775 creator A5063801639 @default.
• W2564683775 creator A5064276936 @default.
• W2564683775 creator A5076821347 @default.
• W2564683775 date "2016-01-01" @default.
• W2564683775 modified "2023-10-05" @default.
• W2564683775 title "Aberrant methylation of <i>CDH13</i> can be a diagnostic biomarker for lung adenocarcinoma" @default.
• W2564683775 cites W1520975359 @default.
• W2564683775 cites W1923482230 @default.
• W2564683775 cites W1937377332 @default.
• W2564683775 cites W1942853403 @default.
• W2564683775 cites W1952134382 @default.
• W2564683775 cites W1969090518 @default.
• W2564683775 cites W1975003033 @default.
• W2564683775 cites W1975174841 @default.
• W2564683775 cites W1980356367 @default.
• W2564683775 cites W1992293996 @default.
• W2564683775 cites W1998715453 @default.
• W2564683775 cites W2014607365 @default.
• W2564683775 cites W2015898468 @default.
• W2564683775 cites W2020541351 @default.
• W2564683775 cites W2023505669 @default.
• W2564683775 cites W2025600112 @default.
• W2564683775 cites W2029654103 @default.
• W2564683775 cites W2041988793 @default.
• W2564683775 cites W2046317081 @default.
• W2564683775 cites W2050619503 @default.
• W2564683775 cites W2058214637 @default.
• W2564683775 cites W2071860733 @default.
• W2564683775 cites W2072679392 @default.
• W2564683775 cites W2090998631 @default.
• W2564683775 cites W2092977532 @default.
• W2564683775 cites W2093078850 @default.
• W2564683775 cites W2097596835 @default.
• W2564683775 cites W2097997050 @default.
• W2564683775 cites W2098141312 @default.
• W2564683775 cites W2107328434 @default.
• W2564683775 cites W2109433604 @default.
• W2564683775 cites W2110845635 @default.
• W2564683775 cites W2126945850 @default.
• W2564683775 cites W2134398282 @default.
• W2564683775 cites W2137503592 @default.
• W2564683775 cites W2142020548 @default.
• W2564683775 cites W2144095151 @default.
• W2564683775 cites W2147357092 @default.
• W2564683775 cites W2150000105 @default.
• W2564683775 cites W2156165856 @default.
• W2564683775 cites W2164050575 @default.
• W2564683775 cites W2170552969 @default.
• W2564683775 cites W2171415670 @default.
• W2564683775 cites W2180481128 @default.
• W2564683775 cites W2182731941 @default.
• W2564683775 cites W2209503093 @default.
• W2564683775 cites W2280308946 @default.
• W2564683775 cites W41135433 @default.
• W2564683775 cites W2154830942 @default.
• W2564683775 doi "https://doi.org/10.7150/jca.15758" @default.
• W2564683775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5166538" @default.
• W2564683775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27994665" @default.
• W2564683775 hasPublicationYear "2016" @default.
• W2564683775 type Work @default.
• W2564683775 sameAs 2564683775 @default.
• W2564683775 citedByCount "24" @default.
• W2564683775 countsByYear W25646837752016 @default.
• W2564683775 countsByYear W25646837752017 @default.
• W2564683775 countsByYear W25646837752018 @default.
• W2564683775 countsByYear W25646837752019 @default.
• W2564683775 countsByYear W25646837752020 @default.
• W2564683775 countsByYear W25646837752021 @default.
• W2564683775 countsByYear W25646837752022 @default.
• W2564683775 countsByYear W25646837752023 @default.
• W2564683775 crossrefType "journal-article" @default.
• W2564683775 hasAuthorship W2564683775A5007806931 @default.
• W2564683775 hasAuthorship W2564683775A5021097559 @default.
• W2564683775 hasAuthorship W2564683775A5021725931 @default.
• W2564683775 hasAuthorship W2564683775A5033286474 @default.
• W2564683775 hasAuthorship W2564683775A5042534727 @default.
• W2564683775 hasAuthorship W2564683775A5050842690 @default.
• W2564683775 hasAuthorship W2564683775A5051169949 @default.
• W2564683775 hasAuthorship W2564683775A5063801639 @default.
• W2564683775 hasAuthorship W2564683775A5064276936 @default.
• W2564683775 hasAuthorship W2564683775A5076821347 @default.
• W2564683775 hasBestOaLocation W25646837751 @default.
• W2564683775 hasConcept C104317684 @default.
• W2564683775 hasConcept C121608353 @default.
• W2564683775 hasConcept C126322002 @default.
• W2564683775 hasConcept C140173407 @default.
• W2564683775 hasConcept C143998085 @default.
• W2564683775 hasConcept C150194340 @default.
• W2564683775 hasConcept C156957248 @default.

• next