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• W2564689890 abstract "Summary. Microangiopathy related cerebral damage (MARCD) includes early confluent and confluent white matter hyperintensities (WMH) and lacu­ nar lesions. It is expected to be the result of interactions between multiple genetic and 'environmental factors. The estimated proportion of genetic factors contributing to the interindividual variation seen in WMH volume is 73%. This estimate points to a significant genetic component in WMH devel­ opment. In the setting of the Austrian Stroke Prevention Study we search for genes being associated with the presence, severity and progression of MARCD using the candidate gene approach. Defining susceptibility genes may allow to better identify individuals at high risk for MARCD and to target preventive measures. Definition of MARCD Microangiopathy-related cerebral damage (MARCD) includes early confluent and confluent white matter changes as well as lacunar infarcts. (Schmidt et aI., 1997). The definition is based on histopathological findings demonstrating that both of these changes are associated with arteriolosclero­ sis (Awald et aI., 1986; Kirkpatrick and Hayman, 1987; Fazekas et aI., 1993; Braffman et aI., 1988; Van Swieten et aI., 1991). They also share common risk factors and have the highest probability to progress (Schmidt et aI., 1999). Punctate WMH which include a plethora of minimal cerebral abnormalities that can not unequivocally be attributed to cerebral ischemia according to pathohistologic correlations (Fazekas et aI., 1991) are excluded from this definition. Although MARCD may be recognized in otherwise normal indi­ viduals it is likely to become associated with cognitive impairment and gait disturbances as it progresses (Pantoni and Garcia, 1995; Longstreth et aI., 1998). So far epidemiological studies could establish arterial hypertension and age as risk factors for this type of brain abnormalities (Van Swieten et aI., 1991; Breteler et aI., 1994; Schmidt et aI., 1997)." @default.
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• W2564689890 date "2000-01-01" @default.
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• W2564689890 title "Genetic aspects of micro angiopathy-related cerebral damage" @default.
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