Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564691372> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2564691372 abstract "To understand relationships between breast tissue and ‘cells of origin’ of breast cancer, it is important to dissect the normal mammary epithelial hierarchy. Discrete populations of mouse and human mammary epithelial cells can be isolated on the basis of cell surface markers and subsets that are highly enriched for mammary stem (MaSC), luminal progenitor and mature luminal cells have been identified. These are functionally analogous across species and have highly conserved transcriptomes. Lineage tracing is an important approach for assessing the stem cell hierarchy as it allows stem and progenitor cell fate to be studied in situ in the context of development, tissue maintenance and disease. Indeed, recent studies in the mammary gland have described unipotent stem cells that appear to control the different stages of development. Here we have combined lineage tracing with a novel three-dimensional (3D) imaging strategy to explore the relative contributions of stem and progenitor cells in the post-natal mammary gland. Newly generated transgenic strains harboring lineage-specific gene regulatory regions are also being used to direct the expression of specific mammary oncogenes to discrete epithelial cell types to gain insight into cells of origin of breast cancer. Citation Format: Anne Rios, Naiyang Fu, Bhupinder Pal, Geoffrey Lindeman, Jane Visvader. Mammary epithelial subtypes and their implications for breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications; Oct 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2013;11(10 Suppl):Abstract nr IA12." @default.
- W2564691372 created "2017-01-06" @default.
- W2564691372 creator A5013309333 @default.
- W2564691372 creator A5024373633 @default.
- W2564691372 creator A5028853436 @default.
- W2564691372 creator A5076938587 @default.
- W2564691372 creator A5087062995 @default.
- W2564691372 date "2013-10-01" @default.
- W2564691372 modified "2023-09-27" @default.
- W2564691372 title "Abstract IA12: Mammary epithelial subtypes and their implications for breast cancer" @default.
- W2564691372 doi "https://doi.org/10.1158/1557-3125.advbc-ia12" @default.
- W2564691372 hasPublicationYear "2013" @default.
- W2564691372 type Work @default.
- W2564691372 sameAs 2564691372 @default.
- W2564691372 citedByCount "0" @default.
- W2564691372 crossrefType "proceedings-article" @default.
- W2564691372 hasAuthorship W2564691372A5013309333 @default.
- W2564691372 hasAuthorship W2564691372A5024373633 @default.
- W2564691372 hasAuthorship W2564691372A5028853436 @default.
- W2564691372 hasAuthorship W2564691372A5076938587 @default.
- W2564691372 hasAuthorship W2564691372A5087062995 @default.
- W2564691372 hasConcept C104317684 @default.
- W2564691372 hasConcept C121608353 @default.
- W2564691372 hasConcept C150194340 @default.
- W2564691372 hasConcept C151730666 @default.
- W2564691372 hasConcept C162317418 @default.
- W2564691372 hasConcept C201750760 @default.
- W2564691372 hasConcept C2776817793 @default.
- W2564691372 hasConcept C2778001805 @default.
- W2564691372 hasConcept C2779343474 @default.
- W2564691372 hasConcept C28328180 @default.
- W2564691372 hasConcept C502942594 @default.
- W2564691372 hasConcept C530470458 @default.
- W2564691372 hasConcept C54355233 @default.
- W2564691372 hasConcept C55427017 @default.
- W2564691372 hasConcept C86803240 @default.
- W2564691372 hasConcept C95444343 @default.
- W2564691372 hasConceptScore W2564691372C104317684 @default.
- W2564691372 hasConceptScore W2564691372C121608353 @default.
- W2564691372 hasConceptScore W2564691372C150194340 @default.
- W2564691372 hasConceptScore W2564691372C151730666 @default.
- W2564691372 hasConceptScore W2564691372C162317418 @default.
- W2564691372 hasConceptScore W2564691372C201750760 @default.
- W2564691372 hasConceptScore W2564691372C2776817793 @default.
- W2564691372 hasConceptScore W2564691372C2778001805 @default.
- W2564691372 hasConceptScore W2564691372C2779343474 @default.
- W2564691372 hasConceptScore W2564691372C28328180 @default.
- W2564691372 hasConceptScore W2564691372C502942594 @default.
- W2564691372 hasConceptScore W2564691372C530470458 @default.
- W2564691372 hasConceptScore W2564691372C54355233 @default.
- W2564691372 hasConceptScore W2564691372C55427017 @default.
- W2564691372 hasConceptScore W2564691372C86803240 @default.
- W2564691372 hasConceptScore W2564691372C95444343 @default.
- W2564691372 hasLocation W25646913721 @default.
- W2564691372 hasOpenAccess W2564691372 @default.
- W2564691372 hasPrimaryLocation W25646913721 @default.
- W2564691372 hasRelatedWork W14965108 @default.
- W2564691372 hasRelatedWork W1547652297 @default.
- W2564691372 hasRelatedWork W1968149876 @default.
- W2564691372 hasRelatedWork W1982560015 @default.
- W2564691372 hasRelatedWork W1985447080 @default.
- W2564691372 hasRelatedWork W1997806103 @default.
- W2564691372 hasRelatedWork W2029711503 @default.
- W2564691372 hasRelatedWork W2056070217 @default.
- W2564691372 hasRelatedWork W2108510784 @default.
- W2564691372 hasRelatedWork W2134607353 @default.
- W2564691372 hasRelatedWork W2135302767 @default.
- W2564691372 hasRelatedWork W2146771808 @default.
- W2564691372 hasRelatedWork W2320309424 @default.
- W2564691372 hasRelatedWork W2565694803 @default.
- W2564691372 hasRelatedWork W2885454032 @default.
- W2564691372 hasRelatedWork W3005748178 @default.
- W2564691372 hasRelatedWork W3006158503 @default.
- W2564691372 hasRelatedWork W3021359121 @default.
- W2564691372 hasRelatedWork W3093571841 @default.
- W2564691372 hasRelatedWork W2551285097 @default.
- W2564691372 isParatext "false" @default.
- W2564691372 isRetracted "false" @default.
- W2564691372 magId "2564691372" @default.
- W2564691372 workType "article" @default.