FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564694582> ?p ?o ?g. }

• W2564694582 abstract "Cyclic AMP binding to G protein-coupled receptors orchestrates chemotaxis and development in Dictyostelium. By activating the RasC-TORC2-AKT/PKB module, cAMP regulates cell polarization during chemotaxis. TORC2 also mediates GPCR-dependent stimulation of adenylyl cyclase A (ACA), enhancing cAMP relay and developmental gene expression. Thus, mutants defective in the TORC2 Pia/Rictor subunit are impaired in chemotaxis and development. Near-saturation mutagenesis of a Pia/Rictor mutant by random gene disruption led to selection of two suppressor mutants, in which spontaneous chemotaxis and development were restored. PKB phosphorylation and chemotactic cell polarization were rescued, whereas Pia/Rictor-dependent ACA stimulation was not restored but bypassed, leading to cAMP-dependent developmental gene expression. Knocking out the gene encoding the adenylylcyclase B (ACB) in the parental strain showed ACB to be essential for this process. The gene tagged in the suppressor mutants encodes a novel HECT ubiquitin ligase, homologous to mammalian HERC1, but harbouring a pleckstrin homology domain. Expression of the isolated HECTwt, but not HECTC5185S, domain was sufficient to reconstitute the parental phenotype. The novel ubiquitin ligase appears to regulate cell sensitivity to cAMP signalling and TORC2-dependent PKB phosphorylation." @default.
• W2564694582 created "2017-01-06" @default.
• W2564694582 creator A5043876644 @default.
• W2564694582 creator A5069626442 @default.
• W2564694582 creator A5084516042 @default.
• W2564694582 date "2017-01-01" @default.
• W2564694582 modified "2023-09-27" @default.
• W2564694582 title "A novel HECT ubiquitin ligase regulating chemotaxis and development in<i>Dictyostelium discoideum</i>" @default.
• W2564694582 cites W1479953545 @default.
• W2564694582 cites W1542771964 @default.
• W2564694582 cites W1542902228 @default.
• W2564694582 cites W1964557313 @default.
• W2564694582 cites W1969053086 @default.
• W2564694582 cites W1977885600 @default.
• W2564694582 cites W1978764703 @default.
• W2564694582 cites W1981613908 @default.
• W2564694582 cites W1983806781 @default.
• W2564694582 cites W1985634710 @default.
• W2564694582 cites W1988932376 @default.
• W2564694582 cites W1990317033 @default.
• W2564694582 cites W1995220259 @default.
• W2564694582 cites W1996479070 @default.
• W2564694582 cites W2001401529 @default.
• W2564694582 cites W2003102209 @default.
• W2564694582 cites W2004250476 @default.
• W2564694582 cites W2005737394 @default.
• W2564694582 cites W2006126837 @default.
• W2564694582 cites W2008044453 @default.
• W2564694582 cites W2008798771 @default.
• W2564694582 cites W2011236413 @default.
• W2564694582 cites W2015273863 @default.
• W2564694582 cites W2020860311 @default.
• W2564694582 cites W2023964272 @default.
• W2564694582 cites W2027729471 @default.
• W2564694582 cites W2027988262 @default.
• W2564694582 cites W2033067702 @default.
• W2564694582 cites W2033144278 @default.
• W2564694582 cites W2035376373 @default.
• W2564694582 cites W2044781023 @default.
• W2564694582 cites W2046990960 @default.
• W2564694582 cites W2050781353 @default.
• W2564694582 cites W2056491244 @default.
• W2564694582 cites W2057002908 @default.
• W2564694582 cites W2063056851 @default.
• W2564694582 cites W2067080420 @default.
• W2564694582 cites W2076185487 @default.
• W2564694582 cites W2083578450 @default.
• W2564694582 cites W2092359053 @default.
• W2564694582 cites W2093663239 @default.
• W2564694582 cites W2096677214 @default.
• W2564694582 cites W2100501804 @default.
• W2564694582 cites W2108374461 @default.
• W2564694582 cites W2108699730 @default.
• W2564694582 cites W2108779387 @default.
• W2564694582 cites W2108819547 @default.
• W2564694582 cites W2109336336 @default.
• W2564694582 cites W2110877055 @default.
• W2564694582 cites W2115358164 @default.
• W2564694582 cites W2117964987 @default.
• W2564694582 cites W2118629804 @default.
• W2564694582 cites W2123785035 @default.
• W2564694582 cites W2123862930 @default.
• W2564694582 cites W2125029383 @default.
• W2564694582 cites W2125709105 @default.
• W2564694582 cites W2128888205 @default.
• W2564694582 cites W2134793907 @default.
• W2564694582 cites W2139103777 @default.
• W2564694582 cites W2146749791 @default.
• W2564694582 cites W2148460267 @default.
• W2564694582 cites W2152185625 @default.
• W2564694582 cites W2156105019 @default.
• W2564694582 cites W2156360989 @default.
• W2564694582 cites W2158040291 @default.
• W2564694582 cites W2159113211 @default.
• W2564694582 cites W2162702728 @default.
• W2564694582 cites W2167300285 @default.
• W2564694582 cites W2170420933 @default.
• W2564694582 cites W2170828577 @default.
• W2564694582 cites W2183780202 @default.
• W2564694582 cites W2271605574 @default.
• W2564694582 cites W2299132688 @default.
• W2564694582 cites W2346113252 @default.
• W2564694582 cites W2414781236 @default.
• W2564694582 cites W4245354300 @default.
• W2564694582 cites W4246993336 @default.
• W2564694582 cites W94487769 @default.
• W2564694582 doi "https://doi.org/10.1242/jcs.194225" @default.
• W2564694582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28049717" @default.
• W2564694582 hasPublicationYear "2017" @default.
• W2564694582 type Work @default.
• W2564694582 sameAs 2564694582 @default.
• W2564694582 citedByCount "9" @default.
• W2564694582 countsByYear W25646945822017 @default.
• W2564694582 countsByYear W25646945822018 @default.
• W2564694582 countsByYear W25646945822019 @default.
• W2564694582 countsByYear W25646945822021 @default.
• W2564694582 countsByYear W25646945822022 @default.
• W2564694582 countsByYear W25646945822023 @default.
• W2564694582 crossrefType "journal-article" @default.
• W2564694582 hasAuthorship W2564694582A5043876644 @default.

• next