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• W2564734506 abstract "9578 Background: Hodgkin’s lymphoma (HL) has an excellent cure rate in pediatric patients. However, survivors are at risk for cardiopulmonary complications from their therapy. Cardiac toxicity includes cardiomyopathy, pericarditis, congestive heart failure, valvular disease, or premature coronary artery disease, while pulmonary complications include pulmonary fibrosis and pneumonitis. Risk factors include anthracycline and bleomycin chemotherapy as well as chest radiation. Methods: A retrospective review examined survivors of HL followed in the CCHMC Cancer Survivor Center. All patients were diagnosed under the age of 21 and were at least 5 years from diagnosis. Cardiopulmonary dysfunction was assessed as ECHO shortening fraction <30% or MUGA ejection fraction <55 and PFT DLCO <80%. Demographic and treatment variables were also examined. Results: 89 patients with HL had an average age of 13.5 (5.0-20.7) years at diagnosis and an average length of follow-up from diagnosis to last ECHO of 10.3 (1.5-29.2) years. There were 45 males. 85 (95%) received anthracycline with an average dose of 220mg/m2 (140-370), 82 (91%) received an average of 70 units/m2 of bleomycin (30-120) and 61 (69%) had chest radiation. Of the 89 patients, 21 (24%) had a cardiac abnormality at any time with 18 (20%) persisting 3+ years from diagnosis. 13 (15%) had a cardiac abnormality 5+ years from diagnosis. 12 of the 13 had a CTC (v3.0) grade of 1 and 1 patient had a grade of 3. Of the13 with cardiac abnormalities, 3 required medications. 44 patients (49%) had a DLCO of less than 80% at some point. This persisted in 23 (25%) at 3+ years and in 15 (17%) patients at 5+ years post therapy. Of that 15, 10 patients had a CTC (v3.0) grade of 2 and 2 patients had a grade of 3. 3 patients were referred to pulmonology. 2 of the 89 patients had both an abnormal SF and DLCO at 5 years. Conclusions: With long follow up about 20% of patients had an abnormal ECHO result with 15% persisting after 5 years. Nearly half of the patients had a DLCO of less than 80%, but most were never symptomatic and did not require intervention. Despite having cardiopulmonary abnormalities at some point in time most will continue to do well. The subset that does develop these complications deserves further investigation." @default.
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• W2564734506 date "2011-05-20" @default.
• W2564734506 modified "2023-09-25" @default.
• W2564734506 title "Cardiopulmonary outcomes in pediatric surivors of Hodgkin's lymphoma." @default.
• W2564734506 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.9578" @default.
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