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- W2564741300 abstract "The study investigated the synergistic effects of combined administration of Ocimum gratissimum and Moringa oleifera in diabetic rats. Seven groups of 6 rats each were used. Groups 1 and 2 representing Normal and Diabetic Control groups (NC and DC respectively) received 0.5ml Dimethyl sulphoxide (DMSO). Groups 3 received 5UI/Kg b.w insulin (intraperitoneally) and group 4 received 5mg/Kg b.w glibenclamide (orally); while groups 5 and 6 received 500mg/Kg b.w of Moringa oleifera (MO) and Ocimum gratissimum (OG) extracts respectively. Group 7 MO + OG (M/O) treated group received 250 mg/ Kg b.w of each extract. There was reduction in electrolyte levels for the extract treated groups when compared with DC. The combined group compared well with NC and INS groups. Bilirubin increased for the treated groups, while urea and creatinine concentrations decreased for the treated groups. Triglyceride (TG), Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL) and Low Density Lipoprotein (LDL) levels reduced in a synergistic manner when compared with DC. High Density Lipoprotein (HDL) increased when compared with DC. These results show the efficacy of the combined extracts at better managing diabetes induced nephropathy in a synergistic pattern when compared with the single extracts and standard drugs insulin and glibenclamide." @default.
- W2564741300 created "2017-01-06" @default.
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- W2564741300 date "2014-01-01" @default.
- W2564741300 modified "2023-09-24" @default.
- W2564741300 title "Ocimum Gratissimum and Moringa Oleifera Ameliorates Diabetic Nephropathy in a Synergistic Manner Similar to Insulin" @default.
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