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- W2564750015 abstract "Oxidative stress, defined as an increase in steady-state levels of superoxide, is involved in the pathogenesis of several cardiovascular diseases. Hypertension is a major risk factor for cardiovascular diseases, and there exists much experimental support for a role of oxidative stress in hypertension, often in association with vascular abnormalities including endothelial dysfunction. Vascular NADPH oxidases (Nox) are by far the most researched topic amongst the sources of reactive oxygen species (ROS) in hypertension, and are thought to be a predominant underlying cause of oxidative stress in hypertension. The purpose of this chapter is to discuss the involvement of oxidative stress in association with vascular abnormalities in animal models of hypertension, with a particular emphasis on evidence for involvement of Nox in three commonly studied models: angiotensin II (Ang II)-induced hypertension, mineralocorticoid-dependent hypertension and the spontaneously hypertensive rat (SHR). Antioxidant defence mechanisms (i.e. superoxide dismutases [SOD]’s and glutathione peroxidases [GPx’s]) may limit vascular oxidative stress, thus experimental evidence discussing their likely protection against vascular oxidative stress and hypertension will be discussed. Recent concepts regarding the link between oxidative stress, the immune system and hypertension will also be covered, and finally we will briefly address clinical data providing an association between oxidative stress and hypertension, in particular the link between genetic abnormalities and oxidative stress in hypertension." @default.
- W2564750015 created "2017-01-06" @default.
- W2564750015 creator A5016982755 @default.
- W2564750015 creator A5029837911 @default.
- W2564750015 creator A5048683932 @default.
- W2564750015 creator A5051677621 @default.
- W2564750015 date "2016-12-23" @default.
- W2564750015 modified "2023-09-23" @default.
- W2564750015 title "Role of Oxidative Stress in Hypertension" @default.
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