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- W2564751780 abstract "Poor sleep quality often results in decreased alertness, drowsi ness and sleepiness the ft)llowing day. Pharmacological treatment of sleep complaints can aggravate these effects, resulting in impaired performance at work and during daily ac tivities such as driving a car. The first hypnotics, the barbitu rates, have a limited safety profile and produce significant day time impairment. They were replaced by the benzodiazepines during the 1970s, which showed to be efficient in the treatment of insomnia but are much safer than the barbiturates. However, bedtime use of benzodiazepines also produces sleepiness and sig nificantly impairs driving performance the following day. The presence and severity of driving impairment varies between ben zodiazepines, depending on their half-life, dosage and time after administration. Nonbenzodiazepines such as zopiclone, Zolpidem and zaleplon were developed to overcome the residual hypnotic effects interfering with daytime performance. Zolpidem showed little to no daytime driving impairment when administered at bedtime, but middle-of-the-night administration is not recom mended for this drug. In contrast, zaleplon (10 mg and 20 mg), administered either at bedtime or in the middle of the night, does not affect driving ability. Therefore, zaleplon is a safe alter native for patients suffering from insomnia that want treatment as needed (during the night when symptoms occur), and are willing to drive a car the following morning." @default.
- W2564751780 created "2017-01-06" @default.
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- W2564751780 date "2006-01-01" @default.
- W2564751780 modified "2023-09-26" @default.
- W2564751780 title "Next-Day Residual EflFects of Sleeping Medications on Driving Ability: A Review of the Literature" @default.
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