FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564751880> ?p ?o ?g. }

• W2564751880 endingPage "1599" @default.
• W2564751880 startingPage "1581" @default.
• W2564751880 abstract "Recently, we have shown that coexpression of hMet and mutant-β-catenin using sleeping beauty transposon/transposase leads to hepatocellular carcinoma (HCC) in mice that corresponds to around 10% of human HCC. In the current study, we investigate whether Ras activation, which can occur downstream of Met signaling, is sufficient to cause HCC in association with mutant-β-catenin. We also tested therapeutic efficacy of targeting β-catenin in an HCC model. We show that mutant-K-Ras (G12D), which leads to Ras activation, cooperates with β-catenin mutants (S33Y, S45Y) to yield HCC in mice. Affymetrix microarray showed > 90% similarity in gene expression in mutant-K-Ras-β-catenin and Met-β-catenin HCC. K-Ras-β-catenin tumors showed up-regulation of β-catenin targets like glutamine synthetase (GS), leukocyte cell-derived chemotaxin 2, Regucalcin, and Cyclin-D1 and of K-Ras effectors, including phosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalian target of rapamycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-binding protein 1, and p-S6 ribosomal protein. Inclusion of dominant-negative transcription factor 4 at the time of K-Ras-β-catenin injection prevented HCC and downstream β-catenin and Ras signaling. To address whether targeting β-catenin has any benefit postestablishment of HCC, we administered K-Ras-β-catenin mice with EnCore lipid nanoparticles (LNP) loaded with a Dicer substrate small interfering RNA targeting catenin beta 1 (CTNNB1; CTNNB1-LNP), scrambled sequence (Scr-LNP), or phosphate-buffered saline for multiple cycles. A significant decrease in tumor burden was evident in the CTNNB1-LNP group versus all controls, which was associated with dramatic decreases in β-catenin targets and some K-Ras effectors, leading to reduced tumor cell proliferation and viability. Intriguingly, in relatively few mice, non-GS-positive tumors, which were evident as a small subset of overall tumor burden, were not affected by β-catenin suppression.Ras activation downstream of c-Met is sufficient to induce clinically relevant HCC in cooperation with mutant β-catenin. β-catenin suppression by a clinically relevant modality is effective in treatment of β-catenin-positive, GS-positive HCCs. (Hepatology 2017;65:1581-1599)." @default.
• W2564751880 created "2017-01-06" @default.
• W2564751880 creator A5004361421 @default.
• W2564751880 creator A5015200436 @default.
• W2564751880 creator A5028462736 @default.
• W2564751880 creator A5029964675 @default.
• W2564751880 creator A5041230460 @default.
• W2564751880 creator A5041601313 @default.
• W2564751880 creator A5082852521 @default.
• W2564751880 creator A5083967189 @default.
• W2564751880 creator A5085330447 @default.
• W2564751880 creator A5086860018 @default.
• W2564751880 date "2017-02-06" @default.
• W2564751880 modified "2023-10-12" @default.
• W2564751880 title "Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice" @default.
• W2564751880 cites W1598910412 @default.
• W2564751880 cites W1969649798 @default.
• W2564751880 cites W1979547006 @default.
• W2564751880 cites W1997769423 @default.
• W2564751880 cites W1998203489 @default.
• W2564751880 cites W2004774286 @default.
• W2564751880 cites W2008777301 @default.
• W2564751880 cites W2009550277 @default.
• W2564751880 cites W2010942899 @default.
• W2564751880 cites W2013273539 @default.
• W2564751880 cites W2013396032 @default.
• W2564751880 cites W2018851752 @default.
• W2564751880 cites W2033267708 @default.
• W2564751880 cites W2041811289 @default.
• W2564751880 cites W2048711000 @default.
• W2564751880 cites W2067036467 @default.
• W2564751880 cites W2067224679 @default.
• W2564751880 cites W2073270386 @default.
• W2564751880 cites W2086229664 @default.
• W2564751880 cites W2087106096 @default.
• W2564751880 cites W2088333494 @default.
• W2564751880 cites W2089041222 @default.
• W2564751880 cites W2093344230 @default.
• W2564751880 cites W2100086304 @default.
• W2564751880 cites W2118151336 @default.
• W2564751880 cites W2136415416 @default.
• W2564751880 cites W2152690616 @default.
• W2564751880 cites W2158378236 @default.
• W2564751880 cites W2174361280 @default.
• W2564751880 cites W2225074830 @default.
• W2564751880 cites W2288959164 @default.
• W2564751880 cites W2294765885 @default.
• W2564751880 cites W2462145367 @default.
• W2564751880 cites W2468296498 @default.
• W2564751880 doi "https://doi.org/10.1002/hep.28975" @default.
• W2564751880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5397318" @default.
• W2564751880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27981621" @default.
• W2564751880 hasPublicationYear "2017" @default.
• W2564751880 type Work @default.
• W2564751880 sameAs 2564751880 @default.
• W2564751880 citedByCount "62" @default.
• W2564751880 countsByYear W25647518802017 @default.
• W2564751880 countsByYear W25647518802018 @default.
• W2564751880 countsByYear W25647518802019 @default.
• W2564751880 countsByYear W25647518802020 @default.
• W2564751880 countsByYear W25647518802021 @default.
• W2564751880 countsByYear W25647518802022 @default.
• W2564751880 countsByYear W25647518802023 @default.
• W2564751880 crossrefType "journal-article" @default.
• W2564751880 hasAuthorship W2564751880A5004361421 @default.
• W2564751880 hasAuthorship W2564751880A5015200436 @default.
• W2564751880 hasAuthorship W2564751880A5028462736 @default.
• W2564751880 hasAuthorship W2564751880A5029964675 @default.
• W2564751880 hasAuthorship W2564751880A5041230460 @default.
• W2564751880 hasAuthorship W2564751880A5041601313 @default.
• W2564751880 hasAuthorship W2564751880A5082852521 @default.
• W2564751880 hasAuthorship W2564751880A5083967189 @default.
• W2564751880 hasAuthorship W2564751880A5085330447 @default.
• W2564751880 hasAuthorship W2564751880A5086860018 @default.
• W2564751880 hasBestOaLocation W25647518801 @default.
• W2564751880 hasConcept C104317684 @default.
• W2564751880 hasConcept C11960822 @default.
• W2564751880 hasConcept C121608353 @default.
• W2564751880 hasConcept C137620995 @default.
• W2564751880 hasConcept C143065580 @default.
• W2564751880 hasConcept C153911025 @default.
• W2564751880 hasConcept C184235292 @default.
• W2564751880 hasConcept C199835354 @default.
• W2564751880 hasConcept C2779324961 @default.
• W2564751880 hasConcept C2779926675 @default.
• W2564751880 hasConcept C29537977 @default.
• W2564751880 hasConcept C30145163 @default.
• W2564751880 hasConcept C502942594 @default.
• W2564751880 hasConcept C54355233 @default.
• W2564751880 hasConcept C62478195 @default.
• W2564751880 hasConcept C86803240 @default.
• W2564751880 hasConcept C95444343 @default.
• W2564751880 hasConceptScore W2564751880C104317684 @default.
• W2564751880 hasConceptScore W2564751880C11960822 @default.
• W2564751880 hasConceptScore W2564751880C121608353 @default.
• W2564751880 hasConceptScore W2564751880C137620995 @default.
• W2564751880 hasConceptScore W2564751880C143065580 @default.
• W2564751880 hasConceptScore W2564751880C153911025 @default.

• next