FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564753067> ?p ?o ?g. }

• W2564753067 endingPage "1751" @default.
• W2564753067 startingPage "1745" @default.
• W2564753067 abstract "Mycobacterium ulcerans is a slow-growing mycobacterium responsible for Buruli ulcer. The pathogenic virulence of MU is being linked to the expression of toxin called Mycolactone, whose form varies according to the origin of the productive strains. Forms A and B are secreted by African and Malaysian strains, C by Australian strains and D by Asian strains. Forms E and F of mycolactone are secreted by animal mycolactone producing mycobacteria strains. The genes for the biosynthesis of Mycolactone are located on a plasmid called pMUM001. We investigated the circulation of Mycolactone in body fluids coupled to the detection of virulence factors in MU strains. Suspicious BU patients and healthy subjects (negative controls) were selected in three Ivorian endemic areas. Exudates, fine needle aspiration (FNA) and blood samples were collected. Microscopy by Ziehl-Neelsen-staining, culture and PCR diagnostics using IS2404 and KR were performed in patient samples. The Mycolactone detection by HLPC coupled to MS was performed in patient and control samples. PCR using IS2404, IS2606, KR and ER were also performed in MU strains. Ziehl-Neelsen-microscopy detected acid-fast bacilli in 19% of samples while PCR were positive in 76.2% for IS2404 and 52.4% for KR. Mycolactone A/B was detected in 31% of exudates and in 42.8% of sera. No Mycolactone was detected in control subjects. 17 strains isolated from exudates possessed both IS2404 and IS2606. 70.6% of those strains were positive for KR and ER gene. The study shows that Mycolactone A/B was actually present in most of BU patients selected in three Ivorian endemic areas. With the methods used we detected very low concentrations in patient fluids. Plasmid and ER gene were found in the majority of MU strains. But they were not found in about 30% of strains. Mycolactone was detected only in patients infected by strains in which plasmid was found. Key words: Buruli ulcer, Mycobacterium ulcerans, insertion sequence, virulence factor, Mycolactone." @default.
• W2564753067 created "2017-01-06" @default.
• W2564753067 creator A5008886619 @default.
• W2564753067 creator A5018681339 @default.
• W2564753067 creator A5019568326 @default.
• W2564753067 creator A5044346534 @default.
• W2564753067 creator A5057125988 @default.
• W2564753067 creator A5059015148 @default.
• W2564753067 creator A5059633807 @default.
• W2564753067 creator A5059800336 @default.
• W2564753067 creator A5069794013 @default.
• W2564753067 creator A5085798856 @default.
• W2564753067 creator A5087451948 @default.
• W2564753067 date "2015-07-15" @default.
• W2564753067 modified "2023-09-27" @default.
• W2564753067 title "Virulence factors expressed by Mycobacterium ulcerans strains: Results of a descriptive study" @default.
• W2564753067 cites W1617759896 @default.
• W2564753067 cites W1989152374 @default.
• W2564753067 cites W1997142992 @default.
• W2564753067 cites W2026226444 @default.
• W2564753067 cites W2029052546 @default.
• W2564753067 cites W2034166604 @default.
• W2564753067 cites W2035462737 @default.
• W2564753067 cites W2038197441 @default.
• W2564753067 cites W2049621474 @default.
• W2564753067 cites W2057339612 @default.
• W2564753067 cites W2071321107 @default.
• W2564753067 cites W2074384053 @default.
• W2564753067 cites W2077408214 @default.
• W2564753067 cites W2096606546 @default.
• W2564753067 cites W2098254741 @default.
• W2564753067 cites W2099098590 @default.
• W2564753067 cites W2100353445 @default.
• W2564753067 cites W2112784073 @default.
• W2564753067 cites W2118425917 @default.
• W2564753067 cites W2119591408 @default.
• W2564753067 cites W2121603293 @default.
• W2564753067 cites W2122295256 @default.
• W2564753067 cites W2139540062 @default.
• W2564753067 cites W2144012279 @default.
• W2564753067 cites W2148274798 @default.
• W2564753067 cites W2150934180 @default.
• W2564753067 cites W2152274483 @default.
• W2564753067 cites W2155646851 @default.
• W2564753067 cites W2164919223 @default.
• W2564753067 cites W2170286890 @default.
• W2564753067 doi "https://doi.org/10.5897/ajmr2015.7393" @default.
• W2564753067 hasPublicationYear "2015" @default.
• W2564753067 type Work @default.
• W2564753067 sameAs 2564753067 @default.
• W2564753067 citedByCount "1" @default.
• W2564753067 countsByYear W25647530672016 @default.
• W2564753067 crossrefType "journal-article" @default.
• W2564753067 hasAuthorship W2564753067A5008886619 @default.
• W2564753067 hasAuthorship W2564753067A5018681339 @default.
• W2564753067 hasAuthorship W2564753067A5019568326 @default.
• W2564753067 hasAuthorship W2564753067A5044346534 @default.
• W2564753067 hasAuthorship W2564753067A5057125988 @default.
• W2564753067 hasAuthorship W2564753067A5059015148 @default.
• W2564753067 hasAuthorship W2564753067A5059633807 @default.
• W2564753067 hasAuthorship W2564753067A5059800336 @default.
• W2564753067 hasAuthorship W2564753067A5069794013 @default.
• W2564753067 hasAuthorship W2564753067A5085798856 @default.
• W2564753067 hasAuthorship W2564753067A5087451948 @default.
• W2564753067 hasBestOaLocation W25647530671 @default.
• W2564753067 hasConcept C104317684 @default.
• W2564753067 hasConcept C142724271 @default.
• W2564753067 hasConcept C2776261420 @default.
• W2564753067 hasConcept C2776870249 @default.
• W2564753067 hasConcept C2777367657 @default.
• W2564753067 hasConcept C2779134260 @default.
• W2564753067 hasConcept C2780374374 @default.
• W2564753067 hasConcept C2780661791 @default.
• W2564753067 hasConcept C523546767 @default.
• W2564753067 hasConcept C54355233 @default.
• W2564753067 hasConcept C60987743 @default.
• W2564753067 hasConcept C71924100 @default.
• W2564753067 hasConcept C86803240 @default.
• W2564753067 hasConcept C89423630 @default.
• W2564753067 hasConceptScore W2564753067C104317684 @default.
• W2564753067 hasConceptScore W2564753067C142724271 @default.
• W2564753067 hasConceptScore W2564753067C2776261420 @default.
• W2564753067 hasConceptScore W2564753067C2776870249 @default.
• W2564753067 hasConceptScore W2564753067C2777367657 @default.
• W2564753067 hasConceptScore W2564753067C2779134260 @default.
• W2564753067 hasConceptScore W2564753067C2780374374 @default.
• W2564753067 hasConceptScore W2564753067C2780661791 @default.
• W2564753067 hasConceptScore W2564753067C523546767 @default.
• W2564753067 hasConceptScore W2564753067C54355233 @default.
• W2564753067 hasConceptScore W2564753067C60987743 @default.
• W2564753067 hasConceptScore W2564753067C71924100 @default.
• W2564753067 hasConceptScore W2564753067C86803240 @default.
• W2564753067 hasConceptScore W2564753067C89423630 @default.
• W2564753067 hasIssue "28" @default.
• W2564753067 hasLocation W25647530671 @default.
• W2564753067 hasOpenAccess W2564753067 @default.
• W2564753067 hasPrimaryLocation W25647530671 @default.
• W2564753067 hasRelatedWork W1537075863 @default.

• next