Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564762079> ?p ?o ?g. }
- W2564762079 endingPage "427" @default.
- W2564762079 startingPage "413" @default.
- W2564762079 abstract "Diabetic nephropathy (DN) is one of the most common microvascular diabetic complications. This study was designed to evaluate the possible protective effect and underlying mechanisms of HO-1 induction in streptozotocin (STZ)-induced early DN in rats. The diabetic rats were divided into three groups: STZ-diabetic, cobalt protoporphyrin (CoPP)-treated diabetic, and zinc protoporphyrin IX (ZnPP)-treated diabetic groups. Compared to the STZ-diabetic group, CoPP-induced HO-1 upregulation improved the diabetic state and renal functional parameters, suppressed the renal proinflammatory marker, NF-κB, abrogated the elevated renal hydroxyprolin, and decreased the enhanced renal nicotinamide adenine dinucleotide phosphate oxidase activity with parallel reduction of urinary oxidative stress markers. On the contrary, treatment with ZnPP abrogated HO-1 levels, aggravated the diabetic condition with further increases in renal oxidative stress, fibrotic and inflammatory markers, and exacerbated renal dysfunction in diabetic animals. These findings suggest that the reduced diabetic renal injury upon HO-1 induction implicates the role of HO-1 induction as a potential treatment for DN." @default.
- W2564762079 created "2017-01-06" @default.
- W2564762079 creator A5041442083 @default.
- W2564762079 creator A5048310014 @default.
- W2564762079 date "2016-12-22" @default.
- W2564762079 modified "2023-10-01" @default.
- W2564762079 title "Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats" @default.
- W2564762079 cites W1490906959 @default.
- W2564762079 cites W1500754345 @default.
- W2564762079 cites W1590579277 @default.
- W2564762079 cites W1963584403 @default.
- W2564762079 cites W1966072632 @default.
- W2564762079 cites W1973664534 @default.
- W2564762079 cites W1974656646 @default.
- W2564762079 cites W1975652164 @default.
- W2564762079 cites W1976077502 @default.
- W2564762079 cites W1976912787 @default.
- W2564762079 cites W1980731788 @default.
- W2564762079 cites W1983519701 @default.
- W2564762079 cites W1984698010 @default.
- W2564762079 cites W1984866856 @default.
- W2564762079 cites W1993362870 @default.
- W2564762079 cites W2000979387 @default.
- W2564762079 cites W2005032654 @default.
- W2564762079 cites W2007108460 @default.
- W2564762079 cites W2008566131 @default.
- W2564762079 cites W2014862688 @default.
- W2564762079 cites W2032621905 @default.
- W2564762079 cites W2034462747 @default.
- W2564762079 cites W2035347961 @default.
- W2564762079 cites W2043325163 @default.
- W2564762079 cites W2049862929 @default.
- W2564762079 cites W2053713912 @default.
- W2564762079 cites W2058910330 @default.
- W2564762079 cites W2059171305 @default.
- W2564762079 cites W2069051470 @default.
- W2564762079 cites W2072443036 @default.
- W2564762079 cites W2073675585 @default.
- W2564762079 cites W2076537489 @default.
- W2564762079 cites W2077825206 @default.
- W2564762079 cites W2090256763 @default.
- W2564762079 cites W2092115819 @default.
- W2564762079 cites W2096089065 @default.
- W2564762079 cites W2097499819 @default.
- W2564762079 cites W2097653082 @default.
- W2564762079 cites W2099816894 @default.
- W2564762079 cites W2099952906 @default.
- W2564762079 cites W2107114596 @default.
- W2564762079 cites W2110276942 @default.
- W2564762079 cites W2111686847 @default.
- W2564762079 cites W2119035254 @default.
- W2564762079 cites W2120049958 @default.
- W2564762079 cites W2122025820 @default.
- W2564762079 cites W2127719372 @default.
- W2564762079 cites W2134023932 @default.
- W2564762079 cites W2137648072 @default.
- W2564762079 cites W2144272243 @default.
- W2564762079 cites W2152603253 @default.
- W2564762079 cites W2152689651 @default.
- W2564762079 cites W2153205117 @default.
- W2564762079 cites W2153769752 @default.
- W2564762079 cites W2253744189 @default.
- W2564762079 cites W2333841537 @default.
- W2564762079 cites W4293247451 @default.
- W2564762079 cites W4324262929 @default.
- W2564762079 doi "https://doi.org/10.1556/2060.103.2016.4.001" @default.
- W2564762079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28229631" @default.
- W2564762079 hasPublicationYear "2016" @default.
- W2564762079 type Work @default.
- W2564762079 sameAs 2564762079 @default.
- W2564762079 citedByCount "12" @default.
- W2564762079 countsByYear W25647620792018 @default.
- W2564762079 countsByYear W25647620792019 @default.
- W2564762079 countsByYear W25647620792020 @default.
- W2564762079 countsByYear W25647620792021 @default.
- W2564762079 countsByYear W25647620792022 @default.
- W2564762079 countsByYear W25647620792023 @default.
- W2564762079 crossrefType "journal-article" @default.
- W2564762079 hasAuthorship W2564762079A5041442083 @default.
- W2564762079 hasAuthorship W2564762079A5048310014 @default.
- W2564762079 hasBestOaLocation W25647620792 @default.
- W2564762079 hasConcept C104317684 @default.
- W2564762079 hasConcept C126322002 @default.
- W2564762079 hasConcept C127561419 @default.
- W2564762079 hasConcept C134018914 @default.
- W2564762079 hasConcept C164027704 @default.
- W2564762079 hasConcept C181199279 @default.
- W2564762079 hasConcept C185592680 @default.
- W2564762079 hasConcept C2776151105 @default.
- W2564762079 hasConcept C2776217839 @default.
- W2564762079 hasConcept C2776914184 @default.
- W2564762079 hasConcept C2777989768 @default.
- W2564762079 hasConcept C2779219270 @default.
- W2564762079 hasConcept C2779280383 @default.
- W2564762079 hasConcept C2779543040 @default.
- W2564762079 hasConcept C2779922275 @default.
- W2564762079 hasConcept C38485361 @default.
- W2564762079 hasConcept C55493867 @default.