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- W2564765237 abstract "Peripheral T-cell lymphoma (PTCL), not otherwise specified (NOS) and angioimmunoblastic T-cell lymphoma (AITL) are the most frequent of more than 20 mature PTCL entities featuring a broad spectrum of morphological, immunophenotypic, molecular and clinical characteristics. Unfortunately, recent progress in understanding the (epi)genetic background of PTCL has not been met with similar advances in treatment. Thus, CHO(E)P [cyclophosphamide, doxorubicin, vincristine, and prednisone (plus etoposide)] remains standard first-line therapy. Patients without comorbidities achieving complete or partial remission proceed to autologous stem cell transplantation. With this approach about 50% of patients survive long-term. Patients relapsing after or progressing during first-line therapy have a dismal prognosis. They receive salvage gemcitabine-therapy followed by allogeneic transplantation whenever possible. After allografting, approximately half of the patients survive long-term; any other treatment is palliative. New drugs investigated in phase II studies achieved response rates between 10% and 30%; long-term remissions are the exception to the rule. While most new drugs are not licensed and not readily available, a plethora of other innovative drugs targeting (epi-)genetic abnormalities are in early development. These, together with combinations of new and old drugs, will hopefully increase response to first-line therapy, bridge more patients to transplantation, and finally improve prognosis for all patients with PTCL." @default.
- W2564765237 created "2017-01-06" @default.
- W2564765237 creator A5002498295 @default.
- W2564765237 creator A5047554635 @default.
- W2564765237 date "2016-12-16" @default.
- W2564765237 modified "2023-10-15" @default.
- W2564765237 title "How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future" @default.
- W2564765237 cites W1484238615 @default.
- W2564765237 cites W1587476434 @default.
- W2564765237 cites W1780920458 @default.
- W2564765237 cites W1875404032 @default.
- W2564765237 cites W1912693401 @default.
- W2564765237 cites W1977878174 @default.
- W2564765237 cites W1979843094 @default.
- W2564765237 cites W1983084203 @default.
- W2564765237 cites W1983559722 @default.
- W2564765237 cites W1992081197 @default.
- W2564765237 cites W1992782604 @default.
- W2564765237 cites W1993685031 @default.
- W2564765237 cites W1999637438 @default.
- W2564765237 cites W2002885336 @default.
- W2564765237 cites W2005089980 @default.
- W2564765237 cites W2007180939 @default.
- W2564765237 cites W2015684600 @default.
- W2564765237 cites W2016783244 @default.
- W2564765237 cites W2021464413 @default.
- W2564765237 cites W2023739525 @default.
- W2564765237 cites W2028078153 @default.
- W2564765237 cites W2032713012 @default.
- W2564765237 cites W2033241503 @default.
- W2564765237 cites W2035086577 @default.
- W2564765237 cites W2035861968 @default.
- W2564765237 cites W2036832665 @default.
- W2564765237 cites W2037452407 @default.
- W2564765237 cites W2041598067 @default.
- W2564765237 cites W2048230273 @default.
- W2564765237 cites W2057910076 @default.
- W2564765237 cites W2059280119 @default.
- W2564765237 cites W2060320162 @default.
- W2564765237 cites W2061337936 @default.
- W2564765237 cites W2062437906 @default.
- W2564765237 cites W2065332604 @default.
- W2564765237 cites W2067999861 @default.
- W2564765237 cites W2069271377 @default.
- W2564765237 cites W2074643584 @default.
- W2564765237 cites W2074678620 @default.
- W2564765237 cites W2075256713 @default.
- W2564765237 cites W2076496614 @default.
- W2564765237 cites W2079116568 @default.
- W2564765237 cites W2080059331 @default.
- W2564765237 cites W2080575969 @default.
- W2564765237 cites W2084267988 @default.
- W2564765237 cites W2087661916 @default.
- W2564765237 cites W2088636620 @default.
- W2564765237 cites W2090877911 @default.
- W2564765237 cites W2091490559 @default.
- W2564765237 cites W2096642590 @default.
- W2564765237 cites W2097788893 @default.
- W2564765237 cites W2098666639 @default.
- W2564765237 cites W2107280148 @default.
- W2564765237 cites W2109716912 @default.
- W2564765237 cites W2113994301 @default.
- W2564765237 cites W2114594238 @default.
- W2564765237 cites W2115655527 @default.
- W2564765237 cites W2116068882 @default.
- W2564765237 cites W2116272602 @default.
- W2564765237 cites W2116639751 @default.
- W2564765237 cites W2120566462 @default.
- W2564765237 cites W2123807140 @default.
- W2564765237 cites W2125847997 @default.
- W2564765237 cites W2127884198 @default.
- W2564765237 cites W2130049805 @default.
- W2564765237 cites W2130410326 @default.
- W2564765237 cites W2131064046 @default.
- W2564765237 cites W2131900456 @default.
- W2564765237 cites W2133267160 @default.
- W2564765237 cites W2134210438 @default.
- W2564765237 cites W2138023339 @default.
- W2564765237 cites W2139891818 @default.
- W2564765237 cites W2143450001 @default.
- W2564765237 cites W2146112074 @default.
- W2564765237 cites W2146146853 @default.
- W2564765237 cites W2149807418 @default.
- W2564765237 cites W2152487909 @default.
- W2564765237 cites W2157105776 @default.
- W2564765237 cites W2158739966 @default.
- W2564765237 cites W2160516333 @default.
- W2564765237 cites W2162389158 @default.
- W2564765237 cites W2169574298 @default.
- W2564765237 cites W2171873783 @default.
- W2564765237 cites W2175216008 @default.
- W2564765237 cites W2182872902 @default.
- W2564765237 cites W2206063761 @default.
- W2564765237 cites W2207837802 @default.
- W2564765237 cites W2231946618 @default.
- W2564765237 cites W2264394109 @default.
- W2564765237 cites W2266142448 @default.
- W2564765237 cites W2268932527 @default.