Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564846737> ?p ?o ?g. }
- W2564846737 endingPage "222" @default.
- W2564846737 startingPage "203" @default.
- W2564846737 abstract "A variety of different mRNA-based drugs are currently in development. This became possible, since major breakthroughs in RNA research during the last decades allowed impressive improvements of translation, stability and delivery of mRNA. This article focuses on antigen-encoding RNA-based vaccines that are either directed against tumors or pathogens. mRNA-encoded vaccines are developed both for preventive or therapeutic purposes. Most mRNA-based vaccines are directly administered to patients. Alternatively, primary autologous cells from cancer patients are modified ex vivo by the use of mRNA and then are adoptively transferred to patients. In the EU no regulatory guidelines presently exist that specifically address mRNA-based vaccines. The existing regulatory framework, however, clearly defines that mRNA-based vaccines in most cases have to be centrally approved. Interestingly, depending on whether RNA-based vaccines are directed against tumors or infectious disease, they are formally considered gene therapy products or not, respectively. Besides an overview on the current clinical use of mRNA vaccines in various therapeutic areas a detailed discussion of the current regulatory situation is provided and regulatory perspectives are discussed." @default.
- W2564846737 created "2017-01-06" @default.
- W2564846737 creator A5000036560 @default.
- W2564846737 creator A5008486712 @default.
- W2564846737 creator A5011084407 @default.
- W2564846737 creator A5015612107 @default.
- W2564846737 creator A5018085687 @default.
- W2564846737 creator A5026861780 @default.
- W2564846737 creator A5027147713 @default.
- W2564846737 creator A5036175709 @default.
- W2564846737 creator A5036257821 @default.
- W2564846737 creator A5067589440 @default.
- W2564846737 creator A5071342393 @default.
- W2564846737 creator A5075617216 @default.
- W2564846737 creator A5079399647 @default.
- W2564846737 creator A5086481435 @default.
- W2564846737 date "2016-12-17" @default.
- W2564846737 modified "2023-10-15" @default.
- W2564846737 title "The European Regulatory Environment of RNA-Based Vaccines" @default.
- W2564846737 cites W1538766821 @default.
- W2564846737 cites W1833523230 @default.
- W2564846737 cites W1939433055 @default.
- W2564846737 cites W1963706689 @default.
- W2564846737 cites W1969760553 @default.
- W2564846737 cites W1972643355 @default.
- W2564846737 cites W1986330488 @default.
- W2564846737 cites W1988620094 @default.
- W2564846737 cites W2006942625 @default.
- W2564846737 cites W2014495927 @default.
- W2564846737 cites W2014992495 @default.
- W2564846737 cites W2025980739 @default.
- W2564846737 cites W2039422212 @default.
- W2564846737 cites W2051665875 @default.
- W2564846737 cites W2054298563 @default.
- W2564846737 cites W2054412308 @default.
- W2564846737 cites W2056877436 @default.
- W2564846737 cites W2058647478 @default.
- W2564846737 cites W2060696356 @default.
- W2564846737 cites W2068514555 @default.
- W2564846737 cites W2071302752 @default.
- W2564846737 cites W2079696222 @default.
- W2564846737 cites W2083958143 @default.
- W2564846737 cites W2085865810 @default.
- W2564846737 cites W2091052259 @default.
- W2564846737 cites W2091828109 @default.
- W2564846737 cites W2096039130 @default.
- W2564846737 cites W2098419906 @default.
- W2564846737 cites W2098448632 @default.
- W2564846737 cites W2104401785 @default.
- W2564846737 cites W2104949861 @default.
- W2564846737 cites W2108706633 @default.
- W2564846737 cites W2109280271 @default.
- W2564846737 cites W2110852884 @default.
- W2564846737 cites W2122078651 @default.
- W2564846737 cites W2135745550 @default.
- W2564846737 cites W2136720677 @default.
- W2564846737 cites W2146445916 @default.
- W2564846737 cites W2162541845 @default.
- W2564846737 cites W2163517233 @default.
- W2564846737 cites W2163968354 @default.
- W2564846737 cites W2186068577 @default.
- W2564846737 cites W2246249321 @default.
- W2564846737 cites W2956482721 @default.
- W2564846737 cites W4241462697 @default.
- W2564846737 cites W81209440 @default.
- W2564846737 doi "https://doi.org/10.1007/978-1-4939-6481-9_13" @default.
- W2564846737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27987152" @default.
- W2564846737 hasPublicationYear "2016" @default.
- W2564846737 type Work @default.
- W2564846737 sameAs 2564846737 @default.
- W2564846737 citedByCount "19" @default.
- W2564846737 countsByYear W25648467372018 @default.
- W2564846737 countsByYear W25648467372019 @default.
- W2564846737 countsByYear W25648467372020 @default.
- W2564846737 countsByYear W25648467372021 @default.
- W2564846737 countsByYear W25648467372022 @default.
- W2564846737 countsByYear W25648467372023 @default.
- W2564846737 crossrefType "book-chapter" @default.
- W2564846737 hasAuthorship W2564846737A5000036560 @default.
- W2564846737 hasAuthorship W2564846737A5008486712 @default.
- W2564846737 hasAuthorship W2564846737A5011084407 @default.
- W2564846737 hasAuthorship W2564846737A5015612107 @default.
- W2564846737 hasAuthorship W2564846737A5018085687 @default.
- W2564846737 hasAuthorship W2564846737A5026861780 @default.
- W2564846737 hasAuthorship W2564846737A5027147713 @default.
- W2564846737 hasAuthorship W2564846737A5036175709 @default.
- W2564846737 hasAuthorship W2564846737A5036257821 @default.
- W2564846737 hasAuthorship W2564846737A5067589440 @default.
- W2564846737 hasAuthorship W2564846737A5071342393 @default.
- W2564846737 hasAuthorship W2564846737A5075617216 @default.
- W2564846737 hasAuthorship W2564846737A5079399647 @default.
- W2564846737 hasAuthorship W2564846737A5086481435 @default.
- W2564846737 hasConcept C104317684 @default.
- W2564846737 hasConcept C105580179 @default.
- W2564846737 hasConcept C111599444 @default.
- W2564846737 hasConcept C149364088 @default.
- W2564846737 hasConcept C54355233 @default.
- W2564846737 hasConcept C67705224 @default.