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- W2564861566 endingPage "55" @default.
- W2564861566 startingPage "48" @default.
- W2564861566 abstract "Different aspects of learning, memory, and cognition are regulated by epigenetic mechanisms such as covalent DNA modifications and histone post-translational modifications. More recently, the modulation of chromatin architecture and nuclear organization is emerging as a key factor in dynamic transcriptional regulation of the post-mitotic neuron. For instance, neuronal activity induces relocalization of gene loci to 'transcription factories', and specific enhancer-promoter looping contacts allow for precise transcriptional regulation. Moreover, neuronal activity-dependent DNA double-strand break formation in the promoter of immediate early genes appears to overcome topological constraints on transcription. Together, these findings point to a critical role for genome topology in integrating dynamic environmental signals to define precise spatiotemporal gene expression programs supporting cognitive processes." @default.
- W2564861566 created "2017-01-06" @default.
- W2564861566 creator A5042440695 @default.
- W2564861566 creator A5090533080 @default.
- W2564861566 date "2017-04-01" @default.
- W2564861566 modified "2023-09-23" @default.
- W2564861566 title "In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory" @default.
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