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- W2564868296 abstract "Background: Poor growth in utero combined with early catch-up postnatally confers an increased relative risk of later life morbidities. These growth patterns areinfluenced by ethnic background. The mechanism for translating this early life programming into later life risk is unknown. Changes to hormonal axes have beenimplicated. This is explored in the present study.Objective and hypotheses: To study the influence of the IGF system on growth, adiposity and BP over the first 4 years among British born South Asian (SA) and WhiteEuropean (WE) children.Methods: Healthy SA (M 45, F22) and WE (M 73, F 64) infants were followed prospectively from birth to age 4 years. Mixed linear regression (MLR) modelling adjustingfor age, sex and ethnicity was used to study the effect of IGF-I and IGFBP-3 levels on anthropometry and systolic BP (SBP) over all time points.Results: At birth, SA were shorter and lighter than WE (P<0.05) but not significantly different in length by 1y, or in weight and BMI by 2y in girls and 4y in boys. Bothgroups had similar triceps (Tr) skinfold thickness (SFT), subscapular (Ss) SFT, IGF-I and IGFBP-3 levels at birth. There was a trend for IGF-I and IGFBP-3 to be higher inSA than WE boys beyond 1y, and the difference became significant for IGF-I at 3y (P=0.046). Over the 4 years, MLR modelling showed that ethnicity was significantlyassociated with height SDS, weight SDS, BMI SDS and SBP (all P values <0.01); IGF-I with weight (P<0.001) and BMI SDS (P=0.003); IGFBP-3 (and not IGF-I) withSsSFT (P=0.001) and SBP (P=0.006); and SBP with age (P=0.009) and TrSFT (P=0.037).Conclusions: Over the first 4 years, ethnicity was significantly associated with height, weight and SBP. From a hormonal perspective, IGFBP-3 but not IGF-I wasassociated with truncal adiposity and systolic BP." @default.
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- W2564868296 date "2011-09-01" @default.
- W2564868296 modified "2023-09-24" @default.
- W2564868296 title "The influence of IGF-I, IGFBP-3 and ethnicity on growth, adiposity and blood pressure over 4 years of life in British born children of South Asian and Western European origin" @default.
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