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• W2564884557 endingPage "1476" @default.
• W2564884557 startingPage "1471" @default.
• W2564884557 abstract "The guanine-rich oligonucleotide (GRO), dGGGGTTGGGG (G4T2G4), has the capacity to form a linear supramolecular polymer known as a G-wire. Individual nucleotides of the component GROs can be functionally modified to serve as site-specific attachment points in the G-wire while not interfering with its self-assembling properties. An amine linker modification to an internal thymine base of the GRO, denoted G4TT*G4, serves as a chemically versatile attachment site.In this work, addition of an alkyl disulfide to G4TT*G4 produces the GRO G4TTdG4 enabling binding to gold nanoparticles via place exchange chemistry. G-wires assembled by combining G4T2G4 and G4TTdG4 were stably maintained in an aqueous environment. Disulfide modified G-wires (DS_G-wire) were then covered with dodecanethiol capped gold nanoparticles in an organic solvent via an interfacial place exchange reaction. Tapping Mode AFM and TEM were used to image G-wires decorated with gold nanoparticles. The specificity of the interfacial place exchange reaction was measured using a fluorometric dye displacement from the gold nanoparticles.The results show that a two component DS_G-wire with an amphipathic tether readily self-assemble as shown by PAGE and TM-AFM. The amphipathic disulfide moiety of DS_G-wires facilitates place exchange chemistry with alkylthiol protected Au nanoparticles across an aqueous-organic interface.Interfacial place exchange is an effective strategy for decorating DS_G-wires with Au nanoparticles.The use of modified G-wire self-assembly combined with a high degree of nanoparticle binding specificity presents another strategy for the use of G-wires as a rigid one-dimensional molecular scaffold with potential applications in nanoscale device construction. This article is part of a Special Issue entitled G-quadruplex Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio." @default.
• W2564884557 created "2017-01-06" @default.
• W2564884557 creator A5014220374 @default.
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• W2564884557 date "2017-05-01" @default.
• W2564884557 modified "2023-09-26" @default.
• W2564884557 title "Interfacial Au nanoparticle decoration of a disulfide modified G-wire" @default.
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• W2564884557 doi "https://doi.org/10.1016/j.bbagen.2016.12.010" @default.
• W2564884557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27989638" @default.
• W2564884557 hasPublicationYear "2017" @default.
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