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• W2564928567 abstract "The biosynthesis of branched alkoxy groups, such as the unique t-butyl group found in a variety of natural products, is still poorly understood. Recently, cystobactamids were isolated and identified from Cystobacter sp as novel antibacterials. These metabolites contain an isopropyl group proposed to be formed using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) methyltransferase. Here, we reconstitute the CysS-catalyzed reaction, on p-aminobenzoate thioester substrates, and demonstrate that it not only catalyzes sequential methylations of a methyl group to form ethyl and isopropyl groups but remarkably also sec-butyl and t-butyl groups. To our knowledge, this is the first in vitro reconstitution of a cobalamin-dependent radical SAM enzyme catalyzing the conversion of a methyl group to a t-butyl group." @default.
• W2564928567 created "2017-01-06" @default.
• W2564928567 creator A5064237607 @default.
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• W2564928567 date "2017-01-25" @default.
• W2564928567 modified "2023-10-18" @default.
• W2564928567 title "Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme" @default.
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• W2564928567 doi "https://doi.org/10.1021/jacs.6b10901" @default.
• W2564928567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6078419" @default.
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