FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564948013> ?p ?o ?g. }

• W2564948013 abstract "Previously we reported that Src-associated-substrate-during-mitosis-of-68kDa (Sam68/KHDRBS1) is pivotal for DNA damage-stimulated NF-κB transactivation of anti-apoptotic genes (Fu et al., 2016). Here we show that Sam68 is critical for genotoxic stress-induced NF-κB activation in the γ-irradiated colon and animal and that Sam68-dependent NF-κB activation provides radioprotection to colon epithelium in vivo. Sam68 deletion diminishes γ-irradiation-triggered PAR synthesis and NF-κB activation in colon epithelial cells (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs to undergo apoptosis in mice post whole-body γ-irradiation (WBIR). Sam68 knockout mice suffer more severe damage in the colon and succumb more rapidly from acute radiotoxicity than the control mice following WBIR. Our results underscore the critical role of Sam68 in orchestrating genotoxic stress-initiated NF-κB activation signaling in the colon tissue and whole animal and reveal the pathophysiological relevance of Sam68-dependent NF-κB activation in colonic cell survival and recovery from extrinsic DNA damage." @default.
• W2564948013 created "2017-01-06" @default.
• W2564948013 creator A5005105291 @default.
• W2564948013 creator A5025791362 @default.
• W2564948013 creator A5037941681 @default.
• W2564948013 creator A5065544513 @default.
• W2564948013 creator A5071465160 @default.
• W2564948013 creator A5074474345 @default.
• W2564948013 date "2016-12-20" @default.
• W2564948013 modified "2023-10-14" @default.
• W2564948013 title "Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice" @default.
• W2564948013 cites W155749767 @default.
• W2564948013 cites W1881072801 @default.
• W2564948013 cites W1952574243 @default.
• W2564948013 cites W1967590038 @default.
• W2564948013 cites W1967766874 @default.
• W2564948013 cites W1970227011 @default.
• W2564948013 cites W1988618725 @default.
• W2564948013 cites W2032027735 @default.
• W2564948013 cites W2036444322 @default.
• W2564948013 cites W2036462969 @default.
• W2564948013 cites W2038078790 @default.
• W2564948013 cites W2042233123 @default.
• W2564948013 cites W2045021854 @default.
• W2564948013 cites W2046589688 @default.
• W2564948013 cites W2070096395 @default.
• W2564948013 cites W2074177924 @default.
• W2564948013 cites W2082231023 @default.
• W2564948013 cites W2093433561 @default.
• W2564948013 cites W2094863064 @default.
• W2564948013 cites W2102146969 @default.
• W2564948013 cites W2107289155 @default.
• W2564948013 cites W2117932700 @default.
• W2564948013 cites W2122044177 @default.
• W2564948013 cites W2132555171 @default.
• W2564948013 cites W2140028624 @default.
• W2564948013 cites W2156442575 @default.
• W2564948013 cites W2162104253 @default.
• W2564948013 cites W2168268248 @default.
• W2564948013 cites W2316716290 @default.
• W2564948013 cites W2496870112 @default.
• W2564948013 cites W2519805400 @default.
• W2564948013 cites W930075017 @default.
• W2564948013 doi "https://doi.org/10.7554/elife.21957" @default.
• W2564948013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5214542" @default.
• W2564948013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27996939" @default.
• W2564948013 hasPublicationYear "2016" @default.
• W2564948013 type Work @default.
• W2564948013 sameAs 2564948013 @default.
• W2564948013 citedByCount "11" @default.
• W2564948013 countsByYear W25649480132017 @default.
• W2564948013 countsByYear W25649480132018 @default.
• W2564948013 countsByYear W25649480132019 @default.
• W2564948013 countsByYear W25649480132020 @default.
• W2564948013 countsByYear W25649480132022 @default.
• W2564948013 countsByYear W25649480132023 @default.
• W2564948013 crossrefType "journal-article" @default.
• W2564948013 hasAuthorship W2564948013A5005105291 @default.
• W2564948013 hasAuthorship W2564948013A5025791362 @default.
• W2564948013 hasAuthorship W2564948013A5037941681 @default.
• W2564948013 hasAuthorship W2564948013A5065544513 @default.
• W2564948013 hasAuthorship W2564948013A5071465160 @default.
• W2564948013 hasAuthorship W2564948013A5074474345 @default.
• W2564948013 hasBestOaLocation W25649480131 @default.
• W2564948013 hasConcept C104317684 @default.
• W2564948013 hasConcept C1292079 @default.
• W2564948013 hasConcept C143425029 @default.
• W2564948013 hasConcept C150194340 @default.
• W2564948013 hasConcept C153911025 @default.
• W2564948013 hasConcept C170493617 @default.
• W2564948013 hasConcept C182704531 @default.
• W2564948013 hasConcept C190283241 @default.
• W2564948013 hasConcept C2777730290 @default.
• W2564948013 hasConcept C502942594 @default.
• W2564948013 hasConcept C552990157 @default.
• W2564948013 hasConcept C55493867 @default.
• W2564948013 hasConcept C62478195 @default.
• W2564948013 hasConcept C86803240 @default.
• W2564948013 hasConcept C95444343 @default.
• W2564948013 hasConceptScore W2564948013C104317684 @default.
• W2564948013 hasConceptScore W2564948013C1292079 @default.
• W2564948013 hasConceptScore W2564948013C143425029 @default.
• W2564948013 hasConceptScore W2564948013C150194340 @default.
• W2564948013 hasConceptScore W2564948013C153911025 @default.
• W2564948013 hasConceptScore W2564948013C170493617 @default.
• W2564948013 hasConceptScore W2564948013C182704531 @default.
• W2564948013 hasConceptScore W2564948013C190283241 @default.
• W2564948013 hasConceptScore W2564948013C2777730290 @default.
• W2564948013 hasConceptScore W2564948013C502942594 @default.
• W2564948013 hasConceptScore W2564948013C552990157 @default.
• W2564948013 hasConceptScore W2564948013C55493867 @default.
• W2564948013 hasConceptScore W2564948013C62478195 @default.
• W2564948013 hasConceptScore W2564948013C86803240 @default.
• W2564948013 hasConceptScore W2564948013C95444343 @default.
• W2564948013 hasFunder F4320306095 @default.
• W2564948013 hasFunder F4320337351 @default.
• W2564948013 hasFunder F4320337354 @default.
• W2564948013 hasLocation W25649480131 @default.
• W2564948013 hasLocation W25649480132 @default.
• W2564948013 hasLocation W25649480133 @default.

• next