Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564975554> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2564975554 abstract "Abstract A certain number of studies have showed that p53 gene transfer has an anti-tumor activity in vitro and in vivo . This study was to evaluate the efficacy and safety of thoracic perfusion of recombinant human adenovirus p53 (rAd-p53, Gendicine) for controlling malignant pleural effusion (MPE). We searched for the relevant studies from the database of MEDLINE, Web of Science, EMBASE, Cochrance Library and CNKI to collect the trials concerning the efficacy and safety of rAd-p53 to treat MPE. Fourteen randomised controlled trials (RCTs) with 879 patients were involved in this analysis. The rAd-p53 combined with chemotherapeutic agents significantly improved the overall response rate (ORR) (P < 0.001; odds ratio = 3.73) and disease control rate (DCR) (P < 0.001; odds ratio = 2.32) of patients with MPE as well as the quality of life (QOL) of patients (P < 0.001; odds ratio = 4.27), compared with that of chemotherapeutic agents alone. In addition, the participation of rAd-p53 did not have an obvious impact on the most of incidence of adverse reactions (AEs) (P < 0.05) except the fever (P < 0.001). However, the fever was self-limited and could be tolerated well. The application of rAd-p53 through thoracic perfusion for treating MPE had a better efficacy and safety, which could be a potential choice for controlling MPE." @default.
- W2564975554 created "2017-01-06" @default.
- W2564975554 creator A5010824788 @default.
- W2564975554 creator A5023513530 @default.
- W2564975554 creator A5024732018 @default.
- W2564975554 creator A5041565577 @default.
- W2564975554 date "2016-12-15" @default.
- W2564975554 modified "2023-10-16" @default.
- W2564975554 title "Evaluation of efficacy and safety for recombinant human adenovirus-p53 in the control of the malignant pleural effusions via thoracic perfusion" @default.
- W2564975554 cites W106794759 @default.
- W2564975554 cites W1510503958 @default.
- W2564975554 cites W1595852449 @default.
- W2564975554 cites W1968337772 @default.
- W2564975554 cites W1969875143 @default.
- W2564975554 cites W2000490976 @default.
- W2564975554 cites W2000694905 @default.
- W2564975554 cites W2010142002 @default.
- W2564975554 cites W2028552358 @default.
- W2564975554 cites W2031118873 @default.
- W2564975554 cites W2058119993 @default.
- W2564975554 cites W2061087218 @default.
- W2564975554 cites W2071826279 @default.
- W2564975554 cites W2077296816 @default.
- W2564975554 cites W2077911820 @default.
- W2564975554 cites W2085776144 @default.
- W2564975554 cites W2114922106 @default.
- W2564975554 cites W2120712387 @default.
- W2564975554 cites W2144694610 @default.
- W2564975554 cites W2168972249 @default.
- W2564975554 cites W2183376119 @default.
- W2564975554 cites W2282927702 @default.
- W2564975554 cites W2314380616 @default.
- W2564975554 cites W2318403078 @default.
- W2564975554 cites W2368029415 @default.
- W2564975554 cites W2413464683 @default.
- W2564975554 cites W2432348515 @default.
- W2564975554 cites W2460319758 @default.
- W2564975554 doi "https://doi.org/10.1038/srep39355" @default.
- W2564975554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5157052" @default.
- W2564975554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27976709" @default.
- W2564975554 hasPublicationYear "2016" @default.
- W2564975554 type Work @default.
- W2564975554 sameAs 2564975554 @default.
- W2564975554 citedByCount "16" @default.
- W2564975554 countsByYear W25649755542017 @default.
- W2564975554 countsByYear W25649755542018 @default.
- W2564975554 countsByYear W25649755542019 @default.
- W2564975554 countsByYear W25649755542020 @default.
- W2564975554 countsByYear W25649755542021 @default.
- W2564975554 countsByYear W25649755542022 @default.
- W2564975554 crossrefType "journal-article" @default.
- W2564975554 hasAuthorship W2564975554A5010824788 @default.
- W2564975554 hasAuthorship W2564975554A5023513530 @default.
- W2564975554 hasAuthorship W2564975554A5024732018 @default.
- W2564975554 hasAuthorship W2564975554A5041565577 @default.
- W2564975554 hasBestOaLocation W25649755541 @default.
- W2564975554 hasConcept C126322002 @default.
- W2564975554 hasConcept C141071460 @default.
- W2564975554 hasConcept C143998085 @default.
- W2564975554 hasConcept C146957229 @default.
- W2564975554 hasConcept C156957248 @default.
- W2564975554 hasConcept C197934379 @default.
- W2564975554 hasConcept C2776232967 @default.
- W2564975554 hasConcept C2779634585 @default.
- W2564975554 hasConcept C71924100 @default.
- W2564975554 hasConcept C90924648 @default.
- W2564975554 hasConcept C95190672 @default.
- W2564975554 hasConceptScore W2564975554C126322002 @default.
- W2564975554 hasConceptScore W2564975554C141071460 @default.
- W2564975554 hasConceptScore W2564975554C143998085 @default.
- W2564975554 hasConceptScore W2564975554C146957229 @default.
- W2564975554 hasConceptScore W2564975554C156957248 @default.
- W2564975554 hasConceptScore W2564975554C197934379 @default.
- W2564975554 hasConceptScore W2564975554C2776232967 @default.
- W2564975554 hasConceptScore W2564975554C2779634585 @default.
- W2564975554 hasConceptScore W2564975554C71924100 @default.
- W2564975554 hasConceptScore W2564975554C90924648 @default.
- W2564975554 hasConceptScore W2564975554C95190672 @default.
- W2564975554 hasIssue "1" @default.
- W2564975554 hasLocation W25649755541 @default.
- W2564975554 hasLocation W25649755542 @default.
- W2564975554 hasLocation W25649755543 @default.
- W2564975554 hasLocation W25649755544 @default.
- W2564975554 hasOpenAccess W2564975554 @default.
- W2564975554 hasPrimaryLocation W25649755541 @default.
- W2564975554 hasRelatedWork W2087623595 @default.
- W2564975554 hasRelatedWork W2137334501 @default.
- W2564975554 hasRelatedWork W2372060966 @default.
- W2564975554 hasRelatedWork W2376438601 @default.
- W2564975554 hasRelatedWork W2378350094 @default.
- W2564975554 hasRelatedWork W2401125325 @default.
- W2564975554 hasRelatedWork W2460818230 @default.
- W2564975554 hasRelatedWork W2796769255 @default.
- W2564975554 hasRelatedWork W3084212778 @default.
- W2564975554 hasRelatedWork W4245293991 @default.
- W2564975554 hasVolume "6" @default.
- W2564975554 isParatext "false" @default.
- W2564975554 isRetracted "false" @default.
- W2564975554 magId "2564975554" @default.
- W2564975554 workType "article" @default.