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- W2564992055 abstract "In this study, we evaluate the anti-inflammatory activity of Eriobotrya japonica(EJ) leaves extract in ovalbumin (OVA)-induced murine asthma model, human tracheal smooth muscle cell (HTSMC) and RAW264.7 cell. Mice were wensitized by intra peritoneal OVA and challenged with nebulized OVA. EJ was administered orally at various doses. Broncho alveolar labage fluid (BALF) was collected 24 h after the final OVA challenge. Quantification of nitric oxide (NO) and eosinophil peroxidase (EPO) assay in BALF was done by colorimetric assay. Levels of interleukin (IL)-4 and IL-13 in BALF and stained with hematoxylin and eosin for assessment of cell infiltration sections were stained with hematoxylin and eosin for assessment of cell infiltration whereas mucus production and goblet cell hyperplasia was studied by periodic acid schiff staining. For in vitro experiment, western blot was done to analyze pERK1/2 expression and NFkB translocation in HTSMC whereas iNOS and COX-2 expression in RAW264.7 cell. EJ, significantly reduced the levels of BALF`s NO, EPO, MMPs, IL-4, IL-13, and serum IgE. It also decreases inflammatory cell infiltration and mucus production. EJ also attenuated the proliferation of HTSMC and inhibits overexpression of ERK 1/2 and NFkB translocation in HTSMC as well as iNOS, COX-2 expression in RAW 264.7 cell. Our results suggest that, EJ possess protective effect against allergic airway inflammation." @default.
- W2564992055 created "2017-01-06" @default.
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- W2564992055 date "2016-09-01" @default.
- W2564992055 modified "2023-09-23" @default.
- W2564992055 title "Eriobotrya japonica extract attenuates the airway inflammation in ovalbumin-induced murine model of asthma" @default.
- W2564992055 hasPublicationYear "2016" @default.
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