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- W2564999972 abstract "Previous studies from our laboratory have demonstrated the presence of adherens and tight junctional proteins in the rat epididymis. While we have shown that the expression of E-cadherin (CDH1) and Claudin-1 (CLDN1) in epididymal principal cells is dependant on testicular factors, there is no information on the molecular regulation of these genes. Both CDH1 and CLDN1 expression are strongly regulated by the transcription factor Snail. Our objective was to determine to role of Snail in the regulation of CDH1 and CLDN1 in the epididymis. Snail was expressed throughout the epididymis and its expression varied as a function of development. Surprisingly, Snail mRNA and protein levels were expressed at high levels in the postnatal rat epididymis when CDH1 and CLDN 1 levels are high. Immunocytochemistry of Snail with cryosections revealed the presence of Snail in the cytoplasm and nuclei of epididymal principal cells. Western blots confirmed the nuclear localization of Snail. Preliminary data using a rat epididymal principal cell line transiently transfected with a Snail expression vector indicates that while Snail mRNA was significantly increased, CLDN1 mRNA levels were unaltered. Together these data suggest that Snail does not regulate CLDN1 levels in the rat epididymis. Supported by NSERC." @default.
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- W2564999972 date "2008-05-01" @default.
- W2564999972 modified "2023-10-16" @default.
- W2564999972 title "Regulation of Claudin-1 by The Transcription Factor Snail in the Rat Epididymis." @default.
- W2564999972 doi "https://doi.org/10.1093/biolreprod/78.s1.107e" @default.
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