FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565005984> ?p ?o ?g. }

• W2565005984 endingPage "7553" @default.
• W2565005984 startingPage "7545" @default.
• W2565005984 abstract "Diagnosis of prostate cancer (PCa) is based on prostate biopsy that is performed when prostate specific antigen (PSA) is persistently altered over time and/or abnormal digital rectal examination is found. Serum PSA levels increase in both PCa and benign prostatic hyperplasia, leading to an increased number of unnecessary biopsies. There is an urgent need to unravel PCa-specific molecular signatures.This study aimed at characterizing a panel of circulating micro RNAs (miRNAs) that could distinguish PCa from benign prostatic hyperplasia in a population of age-matched patients with increased PSA levels. Both miRNAs targeting genes involved in PCa onset and miRNAs whose role in PCa has been highlighted in other studies were included. For this purpose, let-7c, let-7e, let-7i, miR-26a-5p, miR-26b-5p, miR-24-3p, miR-23b-3p, miR-27-b-3p, miR-106a-5p, miR-20b-5p, miR-18b-5p, miR-19b-2-5p, miR-363-3p, miR-497, miR-195, miR-25-3p, miR-30c-5p, miR-622, miR-874-3p, miR-346 and miR-940 were assayed through real-time PCR in 64 patients with PCa and compared with 60 patients with benign prostatic hyperplasia. The ability of miRNAs to predict the stage of disease was also analyzed.Let-7c, let-7e, let-7i, miR-26a-5p, miR-26b-5p, miR-18b-5p and miR-25-3p were able to discriminate patients with PCa from those harboring benign prostatic hyperplasia, both presenting altered PSA levels (>3 ng/mL). MiR-25-3p and miR-18b-5p showed the highest sensitivity and specificity to predict PCa, respectively. The combination of these two miRNAs improved the overall sensitivity. A correlation between pathological Gleason score and miRNA expression levels was reported; miR-363-3p, miR-26a-5p, miR-26b-5p, miR-106a-5p, miR-18b-5p, miR-25-3p and let-7i decreased in expression concomitantly with an increase in malignancy.This study confirms serum miRNAs to be reliable candidates for the development of minimally invasive biomarkers for the diagnosis and prognosis of PCa, particularly in those cases where PSA acts as a flawed marker." @default.
• W2565005984 created "2017-01-06" @default.
• W2565005984 creator A5001615562 @default.
• W2565005984 creator A5005837346 @default.
• W2565005984 creator A5032000935 @default.
• W2565005984 creator A5039994497 @default.
• W2565005984 creator A5046927127 @default.
• W2565005984 creator A5067889624 @default.
• W2565005984 date "2016-12-01" @default.
• W2565005984 modified "2023-10-16" @default.
• W2565005984 title "Different levels of serum microRNAs in prostate cancer and benign prostatic hyperplasia: evaluation of potential diagnostic and prognostic role" @default.
• W2565005984 cites W144423133 @default.
• W2565005984 cites W1487554336 @default.
• W2565005984 cites W1521698887 @default.
• W2565005984 cites W1792788514 @default.
• W2565005984 cites W1818280568 @default.
• W2565005984 cites W1913502161 @default.
• W2565005984 cites W1963691340 @default.
• W2565005984 cites W1966851131 @default.
• W2565005984 cites W1971204432 @default.
• W2565005984 cites W1974725571 @default.
• W2565005984 cites W1980826276 @default.
• W2565005984 cites W1983428971 @default.
• W2565005984 cites W1983675397 @default.
• W2565005984 cites W1984941589 @default.
• W2565005984 cites W2007457544 @default.
• W2565005984 cites W2010040408 @default.
• W2565005984 cites W2013406919 @default.
• W2565005984 cites W2016810184 @default.
• W2565005984 cites W2023388296 @default.
• W2565005984 cites W2025000517 @default.
• W2565005984 cites W2034806022 @default.
• W2565005984 cites W2040182688 @default.
• W2565005984 cites W2041509376 @default.
• W2565005984 cites W2043879482 @default.
• W2565005984 cites W2048603557 @default.
• W2565005984 cites W2050434028 @default.
• W2565005984 cites W2053377105 @default.
• W2565005984 cites W2066195414 @default.
• W2565005984 cites W2066693278 @default.
• W2565005984 cites W2073940463 @default.
• W2565005984 cites W2074664629 @default.
• W2565005984 cites W2078576279 @default.
• W2565005984 cites W2083381199 @default.
• W2565005984 cites W2088694013 @default.
• W2565005984 cites W2091434472 @default.
• W2565005984 cites W2093557716 @default.
• W2565005984 cites W2094193660 @default.
• W2565005984 cites W2097233439 @default.
• W2565005984 cites W2102107106 @default.
• W2565005984 cites W2102890462 @default.
• W2565005984 cites W2115093090 @default.
• W2565005984 cites W2115094397 @default.
• W2565005984 cites W2118238803 @default.
• W2565005984 cites W2120456037 @default.
• W2565005984 cites W2120785986 @default.
• W2565005984 cites W2121293179 @default.
• W2565005984 cites W2123582777 @default.
• W2565005984 cites W2129890460 @default.
• W2565005984 cites W2135810600 @default.
• W2565005984 cites W2142489285 @default.
• W2565005984 cites W2144038313 @default.
• W2565005984 cites W2150536104 @default.
• W2565005984 cites W2150679001 @default.
• W2565005984 cites W2150728173 @default.
• W2565005984 cites W2155979487 @default.
• W2565005984 cites W2163144362 @default.
• W2565005984 cites W2164079778 @default.
• W2565005984 cites W2166471340 @default.
• W2565005984 cites W2168083201 @default.
• W2565005984 cites W2170552969 @default.
• W2565005984 cites W2171220008 @default.
• W2565005984 cites W2257993785 @default.
• W2565005984 cites W2275436558 @default.
• W2565005984 cites W2293426979 @default.
• W2565005984 cites W2400643768 @default.
• W2565005984 cites W2416618443 @default.
• W2565005984 doi "https://doi.org/10.2147/ott.s119027" @default.
• W2565005984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5167485" @default.
• W2565005984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28008272" @default.
• W2565005984 hasPublicationYear "2016" @default.
• W2565005984 type Work @default.
• W2565005984 sameAs 2565005984 @default.
• W2565005984 citedByCount "83" @default.
• W2565005984 countsByYear W25650059842017 @default.
• W2565005984 countsByYear W25650059842018 @default.
• W2565005984 countsByYear W25650059842019 @default.
• W2565005984 countsByYear W25650059842020 @default.
• W2565005984 countsByYear W25650059842021 @default.
• W2565005984 countsByYear W25650059842022 @default.
• W2565005984 countsByYear W25650059842023 @default.
• W2565005984 crossrefType "journal-article" @default.
• W2565005984 hasAuthorship W2565005984A5001615562 @default.
• W2565005984 hasAuthorship W2565005984A5005837346 @default.
• W2565005984 hasAuthorship W2565005984A5032000935 @default.
• W2565005984 hasAuthorship W2565005984A5039994497 @default.
• W2565005984 hasAuthorship W2565005984A5046927127 @default.
• W2565005984 hasAuthorship W2565005984A5067889624 @default.

• next