Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565038384> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2565038384 abstract "B85 Tumorigenesis or carcinogenesis is a multi-step process that is induced primarily by carcinogens leading to the development of cancer. Extensive research in the last few years has revealed that regular consumption of certain fruits, vegetables and dietary products can reduce the risk of acquiring cancers. Curcumin (a diferuloylmethane, the yellow pigment in turmeric) possesses inhibitory effects on growth of a variety of tumor cells by reducing cell proliferation and inducing apoptosis. TRAIL induces apoptosis by binding to specific cell surface death receptors (TRAIL-R1/DR4 and TRAIL-R2/DR5). The objectives of this research were to investigate the mechanisms by which curcumin induced apoptosis in prostate cancer cells, and sensitized TRAIL-resistant LNCaP cells. Curcumin induced apoptosis in PC-3 cells and sensitize TRAIL-resistant LNCaP cells. Curcumin inhibited the expression of Bcl-2 and Bcl-XL, and induced the expression of Bax, Bak, PUMA, Bim, and Noxa in PC-3 and LNCaP cells. Treatment of prostate cancer cells with curcumin resulted in generation of reactive oxygen species and drop in mitochondrial membrane potential. Thus, curcumin sensitized TRAIL-resistant LNCaP cells to undergo apoptosis through multiple mechanisms i.e. regulation of Bcl-2 family members, up-regulation of death receptors and engagement of mitochondrial pathway. The ability of curcumin to enhance the apoptosis-inducing potential of TRAIL, and sensitize TRAIL-resistant LNCaP cells suggests that curcumin may induce fundamental alterations in cell signaling pathways leading to apoptosis. Overall, our results suggest that curcumin alone or in combination with TRAIL can be used as promising new candidate for prostate cancer prevention and/or therapy." @default.
- W2565038384 created "2017-01-06" @default.
- W2565038384 creator A5018742494 @default.
- W2565038384 creator A5038606074 @default.
- W2565038384 creator A5091184409 @default.
- W2565038384 date "2006-12-01" @default.
- W2565038384 modified "2023-09-27" @default.
- W2565038384 title "Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer." @default.
- W2565038384 hasPublicationYear "2006" @default.
- W2565038384 type Work @default.
- W2565038384 sameAs 2565038384 @default.
- W2565038384 citedByCount "0" @default.
- W2565038384 crossrefType "journal-article" @default.
- W2565038384 hasAuthorship W2565038384A5018742494 @default.
- W2565038384 hasAuthorship W2565038384A5038606074 @default.
- W2565038384 hasAuthorship W2565038384A5091184409 @default.
- W2565038384 hasConcept C121608353 @default.
- W2565038384 hasConcept C126322002 @default.
- W2565038384 hasConcept C185592680 @default.
- W2565038384 hasConcept C190283241 @default.
- W2565038384 hasConcept C2778250585 @default.
- W2565038384 hasConcept C2779723316 @default.
- W2565038384 hasConcept C2780192828 @default.
- W2565038384 hasConcept C31573885 @default.
- W2565038384 hasConcept C502942594 @default.
- W2565038384 hasConcept C55493867 @default.
- W2565038384 hasConcept C555283112 @default.
- W2565038384 hasConcept C71924100 @default.
- W2565038384 hasConcept C86803240 @default.
- W2565038384 hasConcept C95444343 @default.
- W2565038384 hasConcept C96232424 @default.
- W2565038384 hasConcept C98274493 @default.
- W2565038384 hasConceptScore W2565038384C121608353 @default.
- W2565038384 hasConceptScore W2565038384C126322002 @default.
- W2565038384 hasConceptScore W2565038384C185592680 @default.
- W2565038384 hasConceptScore W2565038384C190283241 @default.
- W2565038384 hasConceptScore W2565038384C2778250585 @default.
- W2565038384 hasConceptScore W2565038384C2779723316 @default.
- W2565038384 hasConceptScore W2565038384C2780192828 @default.
- W2565038384 hasConceptScore W2565038384C31573885 @default.
- W2565038384 hasConceptScore W2565038384C502942594 @default.
- W2565038384 hasConceptScore W2565038384C55493867 @default.
- W2565038384 hasConceptScore W2565038384C555283112 @default.
- W2565038384 hasConceptScore W2565038384C71924100 @default.
- W2565038384 hasConceptScore W2565038384C86803240 @default.
- W2565038384 hasConceptScore W2565038384C95444343 @default.
- W2565038384 hasConceptScore W2565038384C96232424 @default.
- W2565038384 hasConceptScore W2565038384C98274493 @default.
- W2565038384 hasLocation W25650383841 @default.
- W2565038384 hasOpenAccess W2565038384 @default.
- W2565038384 hasPrimaryLocation W25650383841 @default.
- W2565038384 hasRelatedWork W1485287335 @default.
- W2565038384 hasRelatedWork W1956472481 @default.
- W2565038384 hasRelatedWork W1976317565 @default.
- W2565038384 hasRelatedWork W2043371357 @default.
- W2565038384 hasRelatedWork W2052022352 @default.
- W2565038384 hasRelatedWork W2060708275 @default.
- W2565038384 hasRelatedWork W2062184122 @default.
- W2565038384 hasRelatedWork W2065647535 @default.
- W2565038384 hasRelatedWork W2071255032 @default.
- W2565038384 hasRelatedWork W2074546224 @default.
- W2565038384 hasRelatedWork W2141815306 @default.
- W2565038384 hasRelatedWork W2154783923 @default.
- W2565038384 hasRelatedWork W2159394937 @default.
- W2565038384 hasRelatedWork W2159859707 @default.
- W2565038384 hasRelatedWork W2275566653 @default.
- W2565038384 hasRelatedWork W2326561359 @default.
- W2565038384 hasRelatedWork W2757770663 @default.
- W2565038384 hasRelatedWork W2782056180 @default.
- W2565038384 hasRelatedWork W2787800858 @default.
- W2565038384 hasRelatedWork W3023468034 @default.
- W2565038384 hasVolume "15" @default.
- W2565038384 isParatext "false" @default.
- W2565038384 isRetracted "false" @default.
- W2565038384 magId "2565038384" @default.
- W2565038384 workType "article" @default.