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- W2565055415 abstract "Introduction: Measuring change in FEV1 & COPD patient reported outcomes (PROs) such as SGRQ & TDI, rescue medication use & exacerbations are important to assess the overall effect of therapy in COPD patients (pts). However, the relationship between these changes has been rarely reported. We analysed 23 clinical trials in COPD patients treated with LABA [indacaterol (IND), salmeterol & formoterol], LAMA [glycopyrronium (GLY) & tiotropium] & LABA/LAMA dual bronchodilator (QVA149, fixed-dose combination of IND+GLY) to determine the relationship between change in trough FEV1 & PROs. Methods: Individual patient pooled data from randomised, parallel-group, placebo or active controlled studies (3 to18 months; 23,213 pts) were analysed. Results: A significant correlation between improvement in trough FEV1 & other endpoints was seen: exacerbations Rs = 0.05; rescue medication, SGRQ, TDI r = 0.11-0.16, all p Conclusions: At a population level, statistically significant and clinically relevant relationships exist between improvements in trough FEV1 and COPD PROs, but the correlations are too weak to be useful at an individual patient level." @default.
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- W2565055415 date "2015-09-01" @default.
- W2565055415 modified "2023-09-27" @default.
- W2565055415 title "Relationship between change in trough FEV1and COPD patient outcomes: Pooled analysis of 23 clinical trials in patients with COPD" @default.
- W2565055415 doi "https://doi.org/10.1183/13993003.congress-2015.pa1013" @default.
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