FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565080478> ?p ?o ?g. }

• W2565080478 endingPage "246" @default.
• W2565080478 startingPage "237" @default.
• W2565080478 abstract "Abstract Pestalotiollide B, an analog of dibenzodioxocinones which are inhibitors of cholesterol ester transfer proteins, is produced by Pestalotiopsis microspora NK17. To increase the production of pestalotiollide B, we attempted to eliminate competing polyketide products by deleting the genes responsible for their biosynthesis. We successfully deleted 41 out of 48 putative polyketide synthases (PKSs) in the genome of NK17. Nine of the 41 PKS deleted strains had significant increased production of pestalotiollide B (P &lt; 0.05). For instance, deletion of pks35, led to an increase of pestalotiollide B by 887%. We inferred that these nine PKSs possibly lead to branch pathways that compete for precursors with pestalotiollide B, or that convert the product. Deletion of some other PKS genes such as pks8 led to a significant decrease of pestalotiollide B, suggesting they are responsible for its biosynthesis. Our data demonstrated that improvement of pestalotiollide B production can be achieved by eliminating competing polyketides." @default.
• W2565080478 created "2017-01-06" @default.
• W2565080478 creator A5030597324 @default.
• W2565080478 creator A5040594217 @default.
• W2565080478 creator A5051598252 @default.
• W2565080478 creator A5052441498 @default.
• W2565080478 creator A5058380236 @default.
• W2565080478 creator A5072475826 @default.
• W2565080478 creator A5079286679 @default.
• W2565080478 creator A5085875061 @default.
• W2565080478 date "2017-02-01" @default.
• W2565080478 modified "2023-10-06" @default.
• W2565080478 title "Improved pestalotiollide B production by deleting competing polyketide synthase genes in <i>Pestalotiopsis microspora</i>" @default.
• W2565080478 cites W1908709110 @default.
• W2565080478 cites W1968498359 @default.
• W2565080478 cites W1991415074 @default.
• W2565080478 cites W1992724663 @default.
• W2565080478 cites W1993949659 @default.
• W2565080478 cites W2010091762 @default.
• W2565080478 cites W2016089511 @default.
• W2565080478 cites W2021214912 @default.
• W2565080478 cites W2023254218 @default.
• W2565080478 cites W2028880900 @default.
• W2565080478 cites W2029979826 @default.
• W2565080478 cites W2031290750 @default.
• W2565080478 cites W2040337932 @default.
• W2565080478 cites W2052602128 @default.
• W2565080478 cites W2057679921 @default.
• W2565080478 cites W2059977778 @default.
• W2565080478 cites W2066094688 @default.
• W2565080478 cites W2068549696 @default.
• W2565080478 cites W2075561057 @default.
• W2565080478 cites W2075934694 @default.
• W2565080478 cites W2108313755 @default.
• W2565080478 cites W2128242967 @default.
• W2565080478 cites W2137015675 @default.
• W2565080478 cites W2146109620 @default.
• W2565080478 cites W2150787461 @default.
• W2565080478 cites W2153544371 @default.
• W2565080478 cites W2158714788 @default.
• W2565080478 cites W2160122984 @default.
• W2565080478 cites W2162379022 @default.
• W2565080478 cites W2305474825 @default.
• W2565080478 cites W2346047962 @default.
• W2565080478 cites W2394935621 @default.
• W2565080478 cites W2491554885 @default.
• W2565080478 cites W2615453960 @default.
• W2565080478 cites W752778900 @default.
• W2565080478 doi "https://doi.org/10.1007/s10295-016-1882-z" @default.
• W2565080478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28005187" @default.
• W2565080478 hasPublicationYear "2017" @default.
• W2565080478 type Work @default.
• W2565080478 sameAs 2565080478 @default.
• W2565080478 citedByCount "12" @default.
• W2565080478 countsByYear W25650804782017 @default.
• W2565080478 countsByYear W25650804782018 @default.
• W2565080478 countsByYear W25650804782020 @default.
• W2565080478 countsByYear W25650804782021 @default.
• W2565080478 countsByYear W25650804782022 @default.
• W2565080478 countsByYear W25650804782023 @default.
• W2565080478 crossrefType "journal-article" @default.
• W2565080478 hasAuthorship W2565080478A5030597324 @default.
• W2565080478 hasAuthorship W2565080478A5040594217 @default.
• W2565080478 hasAuthorship W2565080478A5051598252 @default.
• W2565080478 hasAuthorship W2565080478A5052441498 @default.
• W2565080478 hasAuthorship W2565080478A5058380236 @default.
• W2565080478 hasAuthorship W2565080478A5072475826 @default.
• W2565080478 hasAuthorship W2565080478A5079286679 @default.
• W2565080478 hasAuthorship W2565080478A5085875061 @default.
• W2565080478 hasConcept C104317684 @default.
• W2565080478 hasConcept C121807389 @default.
• W2565080478 hasConcept C2777763344 @default.
• W2565080478 hasConcept C2778635478 @default.
• W2565080478 hasConcept C2778805384 @default.
• W2565080478 hasConcept C2780618852 @default.
• W2565080478 hasConcept C29172406 @default.
• W2565080478 hasConcept C54355233 @default.
• W2565080478 hasConcept C553450214 @default.
• W2565080478 hasConcept C55493867 @default.
• W2565080478 hasConcept C59822182 @default.
• W2565080478 hasConcept C86803240 @default.
• W2565080478 hasConceptScore W2565080478C104317684 @default.
• W2565080478 hasConceptScore W2565080478C121807389 @default.
• W2565080478 hasConceptScore W2565080478C2777763344 @default.
• W2565080478 hasConceptScore W2565080478C2778635478 @default.
• W2565080478 hasConceptScore W2565080478C2778805384 @default.
• W2565080478 hasConceptScore W2565080478C2780618852 @default.
• W2565080478 hasConceptScore W2565080478C29172406 @default.
• W2565080478 hasConceptScore W2565080478C54355233 @default.
• W2565080478 hasConceptScore W2565080478C553450214 @default.
• W2565080478 hasConceptScore W2565080478C55493867 @default.
• W2565080478 hasConceptScore W2565080478C59822182 @default.
• W2565080478 hasConceptScore W2565080478C86803240 @default.
• W2565080478 hasFunder F4320323993 @default.
• W2565080478 hasIssue "2" @default.
• W2565080478 hasLocation W25650804781 @default.
• W2565080478 hasOpenAccess W2565080478 @default.
• W2565080478 hasPrimaryLocation W25650804781 @default.

• next