FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565082135> ?p ?o ?g. }

• W2565082135 abstract "The alpha7 nicotinic acetylcholine receptor, encoded by the CHRNA7 gene, has been implicated in various psychiatric and behavioral disorders, including schizophrenia, bipolar disorder, epilepsy, autism, Alzheimer's disease, and Parkinson's disease, and is considered a potential target for therapeutic intervention. 15q13.3 microdeletion syndrome is a rare genetic disorder, caused by submicroscopic deletions on chromosome 15q. CHRNA7 is the only gene in this locus that has been deleted entirely in cases involving the smallest microdeletions. Affected individuals manifest variable neurological and behavioral phenotypes, which commonly include developmental delay/intellectual disability, epilepsy, and autism spectrum disorder. Subsets of patients have short attention spans, aggressive behaviors, mood disorders, or schizophrenia. Previous behavioral studies suggested that Chrna7 deficient mice had attention deficits, but were normal in baseline behavioral responses, learning, memory, and sensorimotor gating. Given a growing interest in CHRNA7-related diseases and a better appreciation of its associated human phenotypes, an in-depth behavioral characterization of the Chrna7 deficient mouse model appeared prudent. This study was designed to investigate whether Chrna7 deficient mice manifest phenotypes related to those seen in human individuals, using an array of 12 behavioral assessments and electroencephalogram (EEG) recordings on freely-moving mice. Examined phenotypes included social interaction, compulsive behaviors, aggression, hyperactivity, anxiety, depression, and somatosensory gating. Our data suggests that mouse behavior and EEG recordings are not sensitive to decreased Chrna7 copy number." @default.
• W2565082135 created "2017-01-06" @default.
• W2565082135 creator A5024073865 @default.
• W2565082135 creator A5029048964 @default.
• W2565082135 creator A5059671235 @default.
• W2565082135 creator A5061873666 @default.
• W2565082135 creator A5068674827 @default.
• W2565082135 date "2017-01-03" @default.
• W2565082135 modified "2023-10-17" @default.
• W2565082135 title "Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes" @default.
• W2565082135 cites W1510973950 @default.
• W2565082135 cites W1515993734 @default.
• W2565082135 cites W1900806927 @default.
• W2565082135 cites W1970629813 @default.
• W2565082135 cites W1972220374 @default.
• W2565082135 cites W1973127620 @default.
• W2565082135 cites W1976101979 @default.
• W2565082135 cites W1984498876 @default.
• W2565082135 cites W1992735105 @default.
• W2565082135 cites W1993890839 @default.
• W2565082135 cites W2009294006 @default.
• W2565082135 cites W2009692159 @default.
• W2565082135 cites W2011109341 @default.
• W2565082135 cites W2012266823 @default.
• W2565082135 cites W2012654451 @default.
• W2565082135 cites W2013013356 @default.
• W2565082135 cites W2024129111 @default.
• W2565082135 cites W2029743369 @default.
• W2565082135 cites W2031355884 @default.
• W2565082135 cites W2038283110 @default.
• W2565082135 cites W2044544988 @default.
• W2565082135 cites W2050161506 @default.
• W2565082135 cites W2058017403 @default.
• W2565082135 cites W2058295614 @default.
• W2565082135 cites W2062616602 @default.
• W2565082135 cites W2066211691 @default.
• W2565082135 cites W2069788048 @default.
• W2565082135 cites W2069933575 @default.
• W2565082135 cites W2074915076 @default.
• W2565082135 cites W2075183590 @default.
• W2565082135 cites W2078754214 @default.
• W2565082135 cites W2081800196 @default.
• W2565082135 cites W2082109123 @default.
• W2565082135 cites W2083595600 @default.
• W2565082135 cites W2085292635 @default.
• W2565082135 cites W2088828914 @default.
• W2565082135 cites W2090019512 @default.
• W2565082135 cites W2090470620 @default.
• W2565082135 cites W2091024890 @default.
• W2565082135 cites W2091478089 @default.
• W2565082135 cites W2094943759 @default.
• W2565082135 cites W2098000677 @default.
• W2565082135 cites W2103189755 @default.
• W2565082135 cites W2115048797 @default.
• W2565082135 cites W2125680814 @default.
• W2565082135 cites W2127848294 @default.
• W2565082135 cites W2128213565 @default.
• W2565082135 cites W2130407782 @default.
• W2565082135 cites W2140383855 @default.
• W2565082135 cites W2140474257 @default.
• W2565082135 cites W2146710322 @default.
• W2565082135 cites W2156922030 @default.
• W2565082135 cites W2160126510 @default.
• W2565082135 cites W2167036812 @default.
• W2565082135 cites W2207327903 @default.
• W2565082135 doi "https://doi.org/10.1038/srep39941" @default.
• W2565082135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5206704" @default.
• W2565082135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28045139" @default.
• W2565082135 hasPublicationYear "2017" @default.
• W2565082135 type Work @default.
• W2565082135 sameAs 2565082135 @default.
• W2565082135 citedByCount "39" @default.
• W2565082135 countsByYear W25650821352017 @default.
• W2565082135 countsByYear W25650821352018 @default.
• W2565082135 countsByYear W25650821352019 @default.
• W2565082135 countsByYear W25650821352020 @default.
• W2565082135 countsByYear W25650821352021 @default.
• W2565082135 countsByYear W25650821352022 @default.
• W2565082135 countsByYear W25650821352023 @default.
• W2565082135 crossrefType "journal-article" @default.
• W2565082135 hasAuthorship W2565082135A5024073865 @default.
• W2565082135 hasAuthorship W2565082135A5029048964 @default.
• W2565082135 hasAuthorship W2565082135A5059671235 @default.
• W2565082135 hasAuthorship W2565082135A5061873666 @default.
• W2565082135 hasAuthorship W2565082135A5068674827 @default.
• W2565082135 hasBestOaLocation W25650821351 @default.
• W2565082135 hasConcept C104317684 @default.
• W2565082135 hasConcept C118552586 @default.
• W2565082135 hasConcept C127716648 @default.
• W2565082135 hasConcept C15744967 @default.
• W2565082135 hasConcept C169760540 @default.
• W2565082135 hasConcept C169900460 @default.
• W2565082135 hasConcept C187869287 @default.
• W2565082135 hasConcept C194544171 @default.
• W2565082135 hasConcept C205778803 @default.
• W2565082135 hasConcept C2776412080 @default.
• W2565082135 hasConcept C2778186239 @default.
• W2565082135 hasConcept C2778538070 @default.
• W2565082135 hasConcept C2779705967 @default.
• W2565082135 hasConcept C54355233 @default.

• next