FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565098539> ?p ?o ?g. }

• W2565098539 endingPage "11" @default.
• W2565098539 startingPage "5" @default.
• W2565098539 abstract "Abstract Triple‐negative breast cancer ( TNBC ) is one of the most aggressive cancers in women. Additionally, presence of residual cancer stem cells ( CSC ) in TNBC has challenged the efficacy of chemotherapy. Thus, the development of new molecules with potential action against CSC is fundamental. In this study, six synthetic analogues of theonelladin C, a 3‐alkylpyridine marine alkaloid, were tested for cytotoxic activity against human TNBC cell line ( BT ‐549) and tumorspheres derived from BT ‐549. Cytotoxicity assay was performed by sulforhodamine B ( SRB ). BT ‐549 and tumorspheres were examined for CD 44 +/high / CD 24 −/low markers, indicative of CSC profile, by flow cytometry. Clonogenic assay was performed to verify inhibiting growth of tumorspheres by the synthetic analogues. Cell death by apoptosis was investigated employing annexin V assay. SRB assay on BT ‐549 cells revealed that compounds 1c and 2c were the most active of the series, with IC 50 values of 18.66 and 9.8 μ m , respectively. Compounds 1c and 2c were able to reduce both CSC ‐like population ( CD 44 +/high / CD 24 −/low ) and non‐ CSC population ( CD 44 +/high / CD 24 +/high ) in tumorsphere model. Clonogenic and annexin V assays confirmed the ability of 1c and 2c to induce growth inhibition and apoptosis in BT ‐549 cells and tumorspheres. These preliminary data indicate that these compounds are a promising class for development of anticancer agents." @default.
• W2565098539 created "2017-01-06" @default.
• W2565098539 creator A5001419285 @default.
• W2565098539 creator A5002313263 @default.
• W2565098539 creator A5007442173 @default.
• W2565098539 creator A5015128651 @default.
• W2565098539 creator A5069943967 @default.
• W2565098539 creator A5077437816 @default.
• W2565098539 creator A5080730364 @default.
• W2565098539 date "2017-02-07" @default.
• W2565098539 modified "2023-10-14" @default.
• W2565098539 title "New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44^+/high/CD24^−/lowsubset of triple-negative breast cancer cell line" @default.
• W2565098539 cites W1757407923 @default.
• W2565098539 cites W1857266517 @default.
• W2565098539 cites W1897354513 @default.
• W2565098539 cites W1971359792 @default.
• W2565098539 cites W1980039397 @default.
• W2565098539 cites W1990365889 @default.
• W2565098539 cites W1995565759 @default.
• W2565098539 cites W1999197880 @default.
• W2565098539 cites W2011002865 @default.
• W2565098539 cites W2023205368 @default.
• W2565098539 cites W2028593825 @default.
• W2565098539 cites W2032007004 @default.
• W2565098539 cites W2051484552 @default.
• W2565098539 cites W2055579080 @default.
• W2565098539 cites W2056853480 @default.
• W2565098539 cites W2064806964 @default.
• W2565098539 cites W2065157239 @default.
• W2565098539 cites W2073605475 @default.
• W2565098539 cites W2075292896 @default.
• W2565098539 cites W2078396922 @default.
• W2565098539 cites W2078532650 @default.
• W2565098539 cites W2086828029 @default.
• W2565098539 cites W2087312216 @default.
• W2565098539 cites W2101681318 @default.
• W2565098539 cites W2110891275 @default.
• W2565098539 cites W2112702770 @default.
• W2565098539 cites W2116504531 @default.
• W2565098539 cites W2120816159 @default.
• W2565098539 cites W2121986702 @default.
• W2565098539 cites W2123370409 @default.
• W2565098539 cites W2132834292 @default.
• W2565098539 cites W2152691024 @default.
• W2565098539 cites W2153423767 @default.
• W2565098539 cites W2161054114 @default.
• W2565098539 cites W2162622637 @default.
• W2565098539 cites W2234203939 @default.
• W2565098539 cites W2344750482 @default.
• W2565098539 cites W43703026 @default.
• W2565098539 doi "https://doi.org/10.1111/cbdd.12923" @default.
• W2565098539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27995747" @default.
• W2565098539 hasPublicationYear "2017" @default.
• W2565098539 type Work @default.
• W2565098539 sameAs 2565098539 @default.
• W2565098539 citedByCount "6" @default.
• W2565098539 countsByYear W25650985392018 @default.
• W2565098539 countsByYear W25650985392019 @default.
• W2565098539 countsByYear W25650985392021 @default.
• W2565098539 countsByYear W25650985392022 @default.
• W2565098539 crossrefType "journal-article" @default.
• W2565098539 hasAuthorship W2565098539A5001419285 @default.
• W2565098539 hasAuthorship W2565098539A5002313263 @default.
• W2565098539 hasAuthorship W2565098539A5007442173 @default.
• W2565098539 hasAuthorship W2565098539A5015128651 @default.
• W2565098539 hasAuthorship W2565098539A5069943967 @default.
• W2565098539 hasAuthorship W2565098539A5077437816 @default.
• W2565098539 hasAuthorship W2565098539A5080730364 @default.
• W2565098539 hasConcept C109316439 @default.
• W2565098539 hasConcept C117262875 @default.
• W2565098539 hasConcept C121608353 @default.
• W2565098539 hasConcept C1491633281 @default.
• W2565098539 hasConcept C154317977 @default.
• W2565098539 hasConcept C185592680 @default.
• W2565098539 hasConcept C190283241 @default.
• W2565098539 hasConcept C202751555 @default.
• W2565098539 hasConcept C2776074239 @default.
• W2565098539 hasConcept C2780110267 @default.
• W2565098539 hasConcept C2780932548 @default.
• W2565098539 hasConcept C28328180 @default.
• W2565098539 hasConcept C2908647359 @default.
• W2565098539 hasConcept C502942594 @default.
• W2565098539 hasConcept C530470458 @default.
• W2565098539 hasConcept C54355233 @default.
• W2565098539 hasConcept C55427017 @default.
• W2565098539 hasConcept C55493867 @default.
• W2565098539 hasConcept C71924100 @default.
• W2565098539 hasConcept C81885089 @default.
• W2565098539 hasConcept C86803240 @default.
• W2565098539 hasConcept C95444343 @default.
• W2565098539 hasConcept C96232424 @default.
• W2565098539 hasConcept C99454951 @default.
• W2565098539 hasConceptScore W2565098539C109316439 @default.
• W2565098539 hasConceptScore W2565098539C117262875 @default.
• W2565098539 hasConceptScore W2565098539C121608353 @default.
• W2565098539 hasConceptScore W2565098539C1491633281 @default.
• W2565098539 hasConceptScore W2565098539C154317977 @default.
• W2565098539 hasConceptScore W2565098539C185592680 @default.

• next