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• W2565110439 abstract "The correlationship between COX-2 gene poly- morphisms and breast cancer has been wildly studied, but the results remain controversial. Hence, the present meta-analysis aimed to investigate the association between COX-2 SNPs (rs5275, rs20417, rs689466, rs5277, rs2206593) and risk of breast cancer. Data were collected from PubMed, Embase and China National Knowledge Infrastructure. Summary odds ratio (OR) with 95 % confidence interval (CI) was applied to assess the relationship. Heterogeneity test, sensitivity analysis and publication bias test were also performed. There were 17 arti- cles that contained 19 studies in this research. Fourteen case- control studies with 15,007 breast cancer cases and 20,005 controls were concerning rs5275 polymorphism, and 8 case- control studies with 10,216 cases and 12,839 controls were about rs20417 polymorphism. Other three polymorphisms (rs689466, rs2206593, rs5277) were studied in 5, 3 and 3 studies, respectively. COX-2-rs20417 CC genotype was sig- nificantly associated with increased risk of breast cancer when comparing to G allele (ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01). Furthermore, the results of the subgroup analysis by ethnicity suggested that C allele significantly contributed to the risk of breast cancer for Asians (1.459 (1.182-1.802) for GC vs. GG, 1.472 (1.201-1.805) for C carrier vs. GG). However, no association was found for rs5275, rs689466, rs5277 and rs2206593 in all comparison modes. This meta-analysis indi- cated that the COX-2 rs20417 polymorphism contributed to genetic susceptibility of breast cancer. In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer." @default.
• W2565110439 created "2017-01-06" @default.
• W2565110439 creator A5012189334 @default.
• W2565110439 creator A5090075204 @default.
• W2565110439 date "2015-01-01" @default.
• W2565110439 modified "2023-09-26" @default.
• W2565110439 title "Five COX-2 gene polymorphisms and risk of breast cancer: an updated meta-analysis based on 19 case-control studies" @default.
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