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- W2565133750 abstract "Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT." @default.
- W2565133750 created "2017-01-06" @default.
- W2565133750 creator A5004433756 @default.
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- W2565133750 creator A5022899551 @default.
- W2565133750 creator A5040396885 @default.
- W2565133750 creator A5051806163 @default.
- W2565133750 date "2017-02-01" @default.
- W2565133750 modified "2023-10-16" @default.
- W2565133750 title "Oxytocin pathways in the intergenerational transmission of maternal early life stress" @default.
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