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• W2565155287 abstract "The assessment and management of pain and anxiety related to a bone marrow aspiration and biopsy (BM asp/bx) has received little attention, despite the frequent use of this procedure, and the availability of safe and rapid-acting IV anesthetics. We sought to quantify the severity of pain and anxiety associated with BM asp/bx and to test a protocol using anesthesiologist-administered IV Propofol to prevent procedure-related pain and anxiety. After signing an informed consent, 82 adult patients (pts) participated in the study. The first 45 pts received a BM asp/bx performed in the routine fashion (control cohort). The next 37 pts participated in the Pain-Free Bone Marrow Protocol and received IV Propofol during their procedure (intervention cohort). Each patient completed pre- and post- BM asp/bx surveys. Visual analogue scales (VAS) were used to measure pain and anxiety/concern. Analysis was performed on the total number of patients for whom complete data was available (Table 1 N=65; Table 2 N=70). A multi-departmental study team was necessary to support the Hematology practice change to incorporate the pain-free BM asp/bx option. | Question | Control n=34 | Intervention n=31 ||:------------------------------------------------------- | ------------ | ----------------- || (VAS: 0=no pain/anxiety 100=most pain/anxiety) *ρ=0.001 || Rate the most severe level of pain | 40 (23–62) | 6 (1–17)* || Rate your expected level of pain for the BM asp/bx | 47 (21–76) | 15 (2–26)* || Rate your pre-BM asp/bx level of anxiety | 37 (11–76) | 29 (7–46) |Bone Marrow Procedure-related Pain and Anxiety: VAS score: Median ( IQ range) | Question | Control N=38 | Intervention N=32 ||:---------------------------------------------------------------------------------------------- | -------------- | ----------------- || *ρ =0.008 **ρ =0.000 (Total Control Group v Total Intervention Group) || How concerned are you about needing a future BM asp/bx? ( VAS: 0= no concern 100=most concern) | 15; 0–45 | 0; 0–6* || Given the choice, would you opt for a pain-free BM asp/bx in the future? | Yes = 15; 44% | Yes = 30; 97%** || | No = 14; 41% | No = 0; 0% || | Unsure = 5;15% | Unsure = 1;0% |Concern for Future Bone Marrow Aspirate/BiopsyPatients in the intervention cohort expected and experienced significantly less pain during their BM asp/bx. Patients in the intervention cohort had less concern regarding possible future BM asp/bx. A meaningful majority of patients would elect a pain-free BM asp/bx in the future if given the option.Our data demonstrate that BM asp/bx performed in the routine fashion is moderately painful and is associated with moderate pre-procedure anxiety. Our protocol using propofol anesthesia successfully reduced expected and experienced BM asp/bx-related pain for the current procedure and potential future procedures.In our sample, the majority of adult hematology patients would elect a pain-free bone marrow aspiration and biopsy procedure if given the option." @default.
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• W2565155287 date "2005-11-16" @default.
• W2565155287 modified "2023-09-27" @default.
• W2565155287 title "Bone Marrow Procedure-Related Pain and Anxiety Improved with Propofol Protocol." @default.
• W2565155287 doi "https://doi.org/10.1182/blood.v106.11.1325.1325" @default.
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