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• W2565216971 startingPage "e1006122" @default.
• W2565216971 abstract "The immunobiology underlying the slow acquisition of skin immunity to group A streptococci (GAS), is not understood, but attributed to specific virulence factors impeding innate immunity and significant antigenic diversity of the type-specific M-protein, hindering acquired immunity. We used a number of epidemiologically distinct GAS strains to model the development of acquired immunity. We show that infection leads to antibody responses to the serotype-specific determinants on the M-protein and profound protective immunity; however, memory B cells do not develop and immunity is rapidly lost. Furthermore, antibodies do not develop to a conserved M-protein epitope that is able to induce immunity following vaccination. However, if re-infected with the same strain within three weeks, enduring immunity and memory B-cells (MBCs) to type-specific epitopes do develop. Such MBCs can adoptively transfer protection to naïve recipients. Thus, highly protective M-protein-specific MBCs may never develop following a single episode of pyoderma, contributing to the slow acquisition of immunity and to streptococcal endemicity in at-risk populations." @default.
• W2565216971 created "2017-01-06" @default.
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• W2565216971 date "2016-12-27" @default.
• W2565216971 modified "2023-10-11" @default.
• W2565216971 title "Streptococcal Immunity Is Constrained by Lack of Immunological Memory following a Single Episode of Pyoderma" @default.
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• W2565216971 doi "https://doi.org/10.1371/journal.ppat.1006122" @default.
• W2565216971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5222516" @default.
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• W2565216971 hasPublicationYear "2016" @default.
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