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• W2565231495 abstract "1. Alexander S. Karageorgiadis, MD*,†2. Charalampos Lyssikatos, MD*3. Elena Belyavskaya, MD*4. Georgios Z. Papadakis, MD‡5. Nicholas J. Patronas, MD‡6. Maya B. Lodish, MD*7. Constantine A. Stratakis, MD, DSc* 1. *Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD2. †Department of Pediatrics, Georgetown University Hospital, Washington, DC3. ‡Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MDAn 11-year-old boy presents to his primary pediatrician due to poor growth. His height was at the 25th percentile between ages 6 and 10 years and now has fallen to the 10th percentile. He also complains of fatigue and has a 1-month history of polyuria, polydipsia, and nocturia. Review of symptoms is negative for weight loss, headaches, vision changes, gynecomastia, breast discharge, nausea, vomiting, and cold and heat intolerance. His past medical and family histories are not contributory and his development has been normal.On physical examination, his temperature is 96.8°F (36oC), blood pressure is 86/52 mm Hg, heart rate is 59 beats/min, respiratory rate is 18 breaths/min, and oxygen saturation is 100% in room air. His standing height is 138.23 cm (10th percentile), weight is 31.5 kg (10th percentile), and body mass index is 16.5 (10th-50th percentile). His neurologic examination yields unremarkable results. His pubic hair is at Sexual Maturity Rating stage 2 and testicular volume of both testes is 10 mL.Laboratory evaluation shows free thyroxine (T4) of 0.76 ng/dL (9.78 pmol/L) (normal range 0.93-1.60 ng/dL [11.97-20.59 pmol/L]), total T4 of 4.3 μg/dL (55.35 nmol/L) (normal range 4.5-12 μg/dL [57.92-154.45 nmol/L]), thyrotropin (TSH) of 1.97 mIU/L (normal range 0.45-4.5 mIU/L), and insulinlike growth factor (IGF-1) of 103 ng/mL (13.49 nmol/L) (normal range for …" @default.
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• W2565231495 date "2017-01-01" @default.
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• W2565231495 title "Case 1: Poor Growth With Presence of a Pituitary Lesion in an 11-year-old Boy" @default.
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• W2565231495 doi "https://doi.org/10.1542/pir.2014-0135" @default.
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