Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565271477> ?p ?o ?g. }
- W2565271477 endingPage "118" @default.
- W2565271477 startingPage "108" @default.
- W2565271477 abstract "Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years of research, there are still many unanswered questions about the cell biology of platelet secretion: for example, how are these secretory organelles organized to support cargo release and what are the key routes of cargo release, granule to plasma membrane or granule to canalicular system. Moreover, in recent years, increasing evidence points to the platelet being organized for secretion of the contents from other organelles, namely the dense tubular system (endoplasmic reticulum) and the Golgi apparatus. Conceivably, protein secretion is a widespread property of the platelet and its organelles. In this review, we concentrate on the cell biology of the α-granule and its structure/function relationships. We both review the literature and discuss the wide array of 3-dimensional, high-resolution structural approaches that have emerged in the last few years. These have begun to reveal new and unanticipated outcomes and some of these are discussed. We are hopeful that the next several years will bring rapid advances to this field that will resolve past controversies and be clinically relevant." @default.
- W2565271477 created "2017-01-06" @default.
- W2565271477 creator A5080378374 @default.
- W2565271477 creator A5085214184 @default.
- W2565271477 date "2016-12-23" @default.
- W2565271477 modified "2023-09-24" @default.
- W2565271477 title "The cellular basis of platelet secretion: Emerging structure/function relationships" @default.
- W2565271477 cites W105396762 @default.
- W2565271477 cites W1500447113 @default.
- W2565271477 cites W1519556359 @default.
- W2565271477 cites W1575016405 @default.
- W2565271477 cites W1581255805 @default.
- W2565271477 cites W1765941213 @default.
- W2565271477 cites W1840874371 @default.
- W2565271477 cites W1905458504 @default.
- W2565271477 cites W1922452462 @default.
- W2565271477 cites W1963398057 @default.
- W2565271477 cites W1965253809 @default.
- W2565271477 cites W1965939153 @default.
- W2565271477 cites W1975705487 @default.
- W2565271477 cites W1976984838 @default.
- W2565271477 cites W1979650786 @default.
- W2565271477 cites W1985238645 @default.
- W2565271477 cites W1990770540 @default.
- W2565271477 cites W1995536857 @default.
- W2565271477 cites W1995601334 @default.
- W2565271477 cites W1996249512 @default.
- W2565271477 cites W1999279640 @default.
- W2565271477 cites W2002964217 @default.
- W2565271477 cites W2005042639 @default.
- W2565271477 cites W2008115239 @default.
- W2565271477 cites W2013531733 @default.
- W2565271477 cites W2021808024 @default.
- W2565271477 cites W2027306662 @default.
- W2565271477 cites W2034893493 @default.
- W2565271477 cites W2041340494 @default.
- W2565271477 cites W2042682762 @default.
- W2565271477 cites W2049206331 @default.
- W2565271477 cites W2055625042 @default.
- W2565271477 cites W2058121024 @default.
- W2565271477 cites W2061597029 @default.
- W2565271477 cites W2069786094 @default.
- W2565271477 cites W2072670197 @default.
- W2565271477 cites W2072816942 @default.
- W2565271477 cites W2074736003 @default.
- W2565271477 cites W2077109373 @default.
- W2565271477 cites W2077939074 @default.
- W2565271477 cites W2086175950 @default.
- W2565271477 cites W2086460801 @default.
- W2565271477 cites W2095423071 @default.
- W2565271477 cites W2104712904 @default.
- W2565271477 cites W2110849911 @default.
- W2565271477 cites W2112129800 @default.
- W2565271477 cites W2112490454 @default.
- W2565271477 cites W2112611562 @default.
- W2565271477 cites W2114507891 @default.
- W2565271477 cites W2126995923 @default.
- W2565271477 cites W2128814992 @default.
- W2565271477 cites W2136719974 @default.
- W2565271477 cites W2150648310 @default.
- W2565271477 cites W2162332322 @default.
- W2565271477 cites W2171903149 @default.
- W2565271477 cites W2178628509 @default.
- W2565271477 cites W2178694631 @default.
- W2565271477 cites W2187790974 @default.
- W2565271477 cites W2192395560 @default.
- W2565271477 cites W2256069431 @default.
- W2565271477 cites W2272593372 @default.
- W2565271477 cites W2274152619 @default.
- W2565271477 cites W2277109157 @default.
- W2565271477 cites W2281589330 @default.
- W2565271477 cites W2289881452 @default.
- W2565271477 cites W2325956083 @default.
- W2565271477 cites W2337603354 @default.
- W2565271477 cites W2341033880 @default.
- W2565271477 cites W2395410748 @default.
- W2565271477 cites W2397983636 @default.
- W2565271477 cites W2398689389 @default.
- W2565271477 cites W2403593392 @default.
- W2565271477 cites W2416869947 @default.
- W2565271477 cites W2418965113 @default.
- W2565271477 cites W2421962974 @default.
- W2565271477 cites W2431898786 @default.
- W2565271477 cites W2518069851 @default.
- W2565271477 cites W2532290661 @default.
- W2565271477 cites W2576830953 @default.
- W2565271477 cites W2793323124 @default.
- W2565271477 cites W302188624 @default.
- W2565271477 cites W3023002297 @default.
- W2565271477 cites W3035833 @default.
- W2565271477 cites W3167320414 @default.
- W2565271477 doi "https://doi.org/10.1080/09537104.2016.1257786" @default.
- W2565271477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5627609" @default.
- W2565271477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28010140" @default.
- W2565271477 hasPublicationYear "2016" @default.
- W2565271477 type Work @default.
- W2565271477 sameAs 2565271477 @default.
- W2565271477 citedByCount "61" @default.